THE CLINICAL AND MORPHOLOGICAL FEATURES OF LATENT PROSTATE CANCER
https://doi.org/10.17650/1726-9776-2009-5-3-40-43
Abstract
The purpose of the study was to provide a retrospective clinicomorphological assessment of the results of examining 70 patients with occult prostate cancer (PC). The findings show it expedient to identify latent prostate cancer as a special clinicomorphological form having a relatively good prognosis. According to the data, surgical or medical antiandrogen blockade had not caused a significant increase in the survival time up to 9 years in these patients and the cause of death was the development of intercurrent diseases rather than tumor progression. Latent cancer is characterized by the following signs:
— detection of only single foci of malignization among a great deal of study tissue pieces) (a tumor in 1—3 out of 20—30 tissue fragments);
— a Gleason score not more than 4;
— detection of Ki-67 in more than 10% of tumor cells;
— the activity of nucleolar organizers up to 3.8;
— a strong reaction to androgen receptors in the majority of tumor cells;
— no p53 hyperexpression;
— a slight or moderate lymphoid or monocytic cell infiltration of the tissues adjacent to the tumor.
The planning of PC management should involve in-depth morphological and molecular genetic analyses.
About the Authors
K. V. Fedosenko
City Clinical Cancer Dispensary, Saint Petersburg
Russian Federation
Russian Federation
P. A. Karlov
City Clinical Cancer Dispensary, Saint Petersburg
Russian Federation
Russian Federation
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Review
For citations:
Fedosenko K.V., Karlov P.A. THE CLINICAL AND MORPHOLOGICAL FEATURES OF LATENT PROSTATE CANCER. Cancer Urology. 2009;5(3):40-43. (In Russ.) https://doi.org/10.17650/1726-9776-2009-5-3-40-43
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