INITIAL EXPERIENCE WITH ADJUVANT INTRAVESICAL THERMOCHEMOTHERAPY FOR NON-MUSCLE INVASIVE BLADDER CANCER
https://doi.org/10.17650/1726-9776-2011-7-1-79-84
Abstract
Objective: to reveal the benefits of adjuvant intravesical thermochemotherapy (TCT) and to evaluate its efficiency in the treatment of moderateand high-risk non-muscle invasive bladder cancer (BC).
Subjects and methods. In the period 2009 to 2010, the Urology Clinic, Federal Medical Biophysical Center, treated 21 patients with nonmuscle invasive BC, by using a Thermotron RF-8 clinical hyperthermal system. Intravesical TCT with mitomycin C 40 mg for 60–80 min was performed at 42 ± 2 °С as one session weekly for 6 weeks. Control cystoscopy was carried out every 3 months.
Results. Of the 21 patients, 19 were found to tolerate the procedure well. No complications were recorded in these patients during the sessions and throughout the course of intravesical TCT. A recurrence was histologically verified in 2 patients at 6-month follow-up. There was no evidence suggesting a recurrence in 12 (57.14 %) patients at one-year follow-up. The follow-up of the other patients is now less than 12 months.
Conclusion. The proposed method of hyperthermia may be used as an alternative to the existing one of intracavitary hyperthermia to treat high- and moderate-risk BC and in case of inefficiency of other adjuvant therapy options for non-muscle invasive BC.
About the Authors
K. A. Pavlenko
Department of Urology, A.I. Burnazyan Federal Medical Biophysical Center, Federal Biomedical Agency of Russia, Moscow
Russian Federation
Russian Federation
A. V. Kochin
Department of Urology, A.I. Burnazyan Federal Medical Biophysical Center, Federal Biomedical Agency of Russia, Moscow
Russian Federation
Russian Federation
T. V. Volkov
Department of Urology, A.I. Burnazyan Federal Medical Biophysical Center, Federal Biomedical Agency of Russia, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Pavlenko K.A., Kochin A.V., Volkov T.V. INITIAL EXPERIENCE WITH ADJUVANT INTRAVESICAL THERMOCHEMOTHERAPY FOR NON-MUSCLE INVASIVE BLADDER CANCER. Cancer Urology. 2011;7(1):79-84. (In Russ.) https://doi.org/10.17650/1726-9776-2011-7-1-79-84
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