THE SPECIFIC FEATURES OF A RESPONSE TO A TYROSINE KINASE INHIBITOR AGAINST DIFFERENT HISTOLOGICAL TYPES OF KIDNEY CANCER (A REVIEW)
https://doi.org/10.17650/1726-9776-2012-8-1-31-35
Abstract
The paper deals with the results of a clinical trial covering patients with disseminated renal cell carcinoma of different histological types, who had no benefits from previous systemic therapy. The response of different histological types of kidney cancer to therapy with tyrosine kinase inhibitors, to sorafenib in particular, was studied within the trial. The findings strongly suggest that mainly patients with clear-cell renal cell carcinoma could achieve complete or partial remission.
About the Authors
A. D. Kaprin
People’s Friendship University of Russia, Moscow
Russian Federation
Department of Urology with a Course of Oncourology
Russian Federation
Department of Urology with a Course of Oncourology
A. A. Kostin
People’s Friendship University of Russia, Moscow
Russian Federation
Department of Urology with a Course of Oncourology
Russian Federation
Department of Urology with a Course of Oncourology
V. V. Alekseev
People’s Friendship University of Russia, Moscow
Russian Federation
Department of Urology with a Course of Oncourology
Russian Federation
Department of Urology with a Course of Oncourology
A. Yu. Varakina
People’s Friendship University of Russia, Moscow
Russian Federation
Department of Urology with a Course of Oncourology
Russian Federation
Department of Urology with a Course of Oncourology
References
1. Chowdhury S., Choueiri T.K. Recent advances in the systemic treatment of metastatic papillary renal cancer. Expert Rev Anticancer Ther 2009;9(3):373−9.
2. Escudier B., Eisen T., Stadler W.M. et al. Sorafenib for treatment of renal cell carcinoma: Final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial. J Clin Oncol 2009;27:3312−8.
3. Choueiri T.K., Plantade A., Elson P. et al. Efficacy of sunitinib and sorafenib in metastatic papilarry and chromophobe renal cell carcinoma. J Clin Oncol 2008;26(1):127−31.
4. Porta C., Bracarda J., Beck J. et al. Efficacy and safety of sorafenib in elderly patients: results from a large open-label, non-comparative phase III study in European patients with advanced RCC (EU-ARCCS). Ann Oncol 2008;19 (suppl 8):193.
5. Wilhelm S.M., Carter C., Tang L. et al. BAY 43-9006 exhibits broad spectrum oral … in tumor progression and angiogenesis. Cancer Res 2004;64:7099−109 .
6. Avila M.A., Berasain C., Sangro B., Prieto J. New therapies for hepatocellular carcinoma. Oncogene 2006;25:3866−84.
7. Liu L., Cao Y., Chen C. et al. Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res 2006;66:11851–8.
8. Semela D., Dufour J.F. et al. Angiogenesis and hepatocellular carcinoma. J Hepatol 2004;41:864−80.
9. Escudier B., Eisen T., Stadler W.M. et al. Sorafenib for treatment of renal cell carcinoma: Final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial. J Clin Oncol 2009;27:3312−8.
10. Escudier B., Eisen T., Stadler W.M. et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med. 2007; 356:125−34.
Review
For citations:
Kaprin A.D., Kostin A.A., Alekseev V.V., Varakina A.Yu. THE SPECIFIC FEATURES OF A RESPONSE TO A TYROSINE KINASE INHIBITOR AGAINST DIFFERENT HISTOLOGICAL TYPES OF KIDNEY CANCER (A REVIEW). Cancer Urology. 2012;8(1):31-35. (In Russ.) https://doi.org/10.17650/1726-9776-2012-8-1-31-35
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