DIAGNOSTIC VALUE OF TRF1 AND MMP-7 AGAINST VARIOUS PROSTATE NEOPLASMS
https://doi.org/10.17650/1726-9776-2011-7-1-31-36
Abstract
The authors analyzed the relative levels of telomeric repeat-binding protein factor 1 (TRF1) and matrix metalloproteinase-7 (MMR-7) mRNA expression by the cells obtained from prostate biopsy specimens of patients with benign prostate hyperplasia and cancer (PC) and healthy men without visible prostate diseases and calculated a TRF1/MMR-7 expression ratio for the above conditions. There was a statistically significant difference in the levels of TRF1 and MMP-7 expression and TRF1/MMP-7 ratio in the study groups, which may be suggestive of the high diagnostic value of these markers in determining the early-stage of PC and which enables clinicians to make a more accurate diagnosis in patients with various urologic diseases.
About the Authors
V. P. Avdoshin
Department of Urology and Surgical Nephrology, Russian Peoples Friendship University, Moscow
Russian Federation
Russian Federation
S. A. Apryatin
Moscow Research Institute of Medical Ecology, Moscow Department of Healthcare
Russian Federation
Russian Federation
S. A. Pulbere
Department of Urology and Surgical Nephrology, Russian Peoples Friendship University, Moscow
Russian Federation
Russian Federation
S. A. Gordeev
Moscow Research Institute of Medical Ecology, Moscow Department of Healthcare
Russian Federation
Russian Federation
A. I. Glukhov
Moscow Research Institute of Medical Ecology, Moscow Department of Healthcare
Department of Biochemistry, I.M. Sechenov Moscow State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Avdoshin V.P., Apryatin S.A., Pulbere S.A., Gordeev S.A., Glukhov A.I. DIAGNOSTIC VALUE OF TRF1 AND MMP-7 AGAINST VARIOUS PROSTATE NEOPLASMS. Cancer Urology. 2011;7(1):31-36. (In Russ.) https://doi.org/10.17650/1726-9776-2011-7-1-31-36
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