MOLECULAR GENETIC DISORDERS IN THE VHL GENE AND METHYLATION OF SOME SUPPRESSOR GENES IN SPORADIC CLEAR-CELL RENAL CARCINOMAS
https://doi.org/10.17650/1726-9776-2010-6-2-32-37
Abstract
About the Authors
D. S. MikhailenkoRussian Federation
M. V. Grigoryeva
Russian Federation
V. V. Zemlyakova
Russian Federation
V. V. Shkarupo
Russian Federation
E. S. Yakovleva
Russian Federation
D. A. Nosov
Russian Federation
L. N. Lyubchenko
Russian Federation
S. A. Tyulyandin
Russian Federation
R. V. Kurynin
Russian Federation
A. M. Popov
Russian Federation
D. V. Zaletayev
Russian Federation
I. G. Rusakov
Russian Federation
References
1. Давыдов М.И., Аксель Е.М. Заболева-емость злокачественными новообразо-ваниями населения России и стран СНГ в 2006 г. Вестн РОНЦ им. Н.Н. Блохина РАМН 2008;19(2 прил 1):6-9.
2. Cheng L., Zhang S., MacLennan G.T. et al. Molecular and cytogenetic insights into the pathogenesis, classification, differential diagnosis, and prognosis of renal epithelial neoplasms. Hum Pathol 2009;40:10-29.
3. Михайленко Д.С., Немцова М.В. Молекулярно-генетические маркеры рака почки. Рос онкол журн 2007;(4):48-51.
4. Михайленко Д.С., Курынин Р.В., По-пов А.М. и др. Инактивация гена VHL при спорадическом светлоклеточном раке почки. Мол Биол 2008;42(1):71-7.
5. Dalgin G.S., Drever M., Williams T. et al. Identification of novel epigenetic markers for clear cell renal cell carcinoma. J Urol 2008;180:1126-30.
6. Херрингтон С., Макги Д. Молекулярная клиническая диагностика. Пер. с англий-ского. М.: Мир, 1999.
7. Kuwai T., Kitadai Y., Tanaka S. et al. Mutation of the von Hippel -Lindau (VHL) gene in human colorectal carcinoma: association with cytoplasmic accumulation of hypoxia-inducible factor (HIF)-1alpha. Cancer Sci 2004;95:149-53.
8. Михайленко Д.С., Попов А.М., Куры-нин Р.В. и др. Поиск и характеристика молекулярно-генетических маркеров спо-радического рака почки. Вестн НИИ мо-лекулярной медицины 2008;(8):52-73.
9. Esteller M. DNA methylation: approaches, methods and applications. Atlanta: CRC Press LLC, 2005.
10. Smits K.M., Schouten L.J., Dijk B.A. et al. Genetic and epigenetic alterations in the von Hippel -Lindau gene: the influence on renal cancer prognosis. Clin Cancer Res 2008;14:782-7.
11. Sudarshan S., Linehan W.M. Genetic basis of cancer of the kidney. Semin Oncol 2006;33:544-51
12. Nickerson M.L., Jaeger E., Shi Y. et al. Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors. Clin Cancer Res 2008;14:4726-34.
13. Wood C.G. Multimodal approaches in the management of locally advanced and metastatic renal cell carcinoma: Combining surgery and systemic therapies to improve patient outcome. Clin Cancer Res 2007;13(2):697-702.
14. Алексеев Б.Я., Шегай П.В. Таргетная терапия распространенного рака почки. Онкоурология 2007;(4):6-11.
15. Choueiri T.K., Vaziri S.A., Jaeger E. et al. Von Hippel-Lindau gene status and response to vascular endothelial growth factor targeted therapy for metastatic clear cell renal cell carcinoma. J Urol 2008;180:860-6.
16. Hoque M.O., Begum S., Topaloglu O. et al. Quantitative detection of promoter hypermethylation of multiple genes in the tumor, urine, and serum DNA of patients with renal cancer. Cancer Res 2004;64:5511-7.
17. Hesson L.B., Cooper W.N., Latif F. The role of RASSF1 A methylation in cancer. Dis Mark 2007;23:73-87.
18. Tezval H., Merseburger A.S.,Matuschek I. et al. RASSF1 A protein expression and correlation with clinicopathological parameters in renal cell carcinoma. BMC Urol 2008:8:12.
19. Costa V.L., Henrique R., Ribeiro F.R. et al. Quantitative promoter methylation analysis of multiple cancer-related genes in renal cell tumors. BMC Cancer 2007;7:133.
Review
For citations:
Mikhailenko D.S., Grigoryeva M.V., Zemlyakova V.V., Shkarupo V.V., Yakovleva E.S., Nosov D.A., Lyubchenko L.N., Tyulyandin S.A., Kurynin R.V., Popov A.M., Zaletayev D.V., Rusakov I.G. MOLECULAR GENETIC DISORDERS IN THE VHL GENE AND METHYLATION OF SOME SUPPRESSOR GENES IN SPORADIC CLEAR-CELL RENAL CARCINOMAS. Cancer Urology. 2010;6(2):32-37. (In Russ.) https://doi.org/10.17650/1726-9776-2010-6-2-32-37