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СLINICAL EXAMPLES OF THE EFFICACY OF BEVACIZUMAB + INTERFERON-ALPHA IN LOW DOSES IN PATIENTS WITH ADVANCED RENAL CELL CARCINOMA

https://doi.org/10.17650/1726-9776-2012-8-2-28-31

Abstract

We present clinical examples of effective use of bevacizumab with low doses of interferon alfa in the treatment of metastatic renal cell carcinoma.

About the Authors

A. M. Popov
Medical Radiology Research Center, Russian Academy of Medical Sciences,Obninsk
Russian Federation


O. B. Karyakin
Medical Radiology Research Center, Russian Academy of Medical Sciences,Obninsk
Russian Federation


References

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2. Sternberg C.N., Davis I.D., Mardiak J. et al. Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial. J Clin Oncol 2010;28(6):1061−8.

3. Escudier B., Pluzanska A., Koralewski P. et al. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial. Lancet. 2007 Dec 22;370(9605):2103−11.

4. Melichar B. et al. BEVLiN: Prospective study of the safety and efficacy of first-line bevacizumab (BEV) plus low-dose interferon-α2a (IFN) in patients (pts) with metastatic renal cell carcinoma (mRCC). 2011 ASCO Annual Meeting, abstr. 4546

5. Попов А.М., Карякин О.Б., Горбань Н.А. Собственный опыт применения комбинации бевацизумаб + интерферон α-2А у больных диссеминированным почечно-клеточным раком. Онкоурология 2010;4:32−5.

6. Albiges L., Oudard S., Negrier S. et al. Complete remission with tyrosine kinase inhibitors in renal cell carcinoma. J Clin Oncol 2012;30(5):482−7.

7. Johannsen M., Flörcken A., Bex A. et al. Can tyrosine kinase inhibitors be discontinued in patients with metastatic renal cell carcinoma and a complete response to treatment? A multicentre, retrospective analysis. Eur Urol 2009;55(6):1430−8.


Review

For citations:


Popov A.M., Karyakin O.B. СLINICAL EXAMPLES OF THE EFFICACY OF BEVACIZUMAB + INTERFERON-ALPHA IN LOW DOSES IN PATIENTS WITH ADVANCED RENAL CELL CARCINOMA. Cancer Urology. 2012;8(2):28-31. (In Russ.) https://doi.org/10.17650/1726-9776-2012-8-2-28-31

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ISSN 1726-9776 (Print)
ISSN 1996-1812 (Online)
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