HISTOSPECTROPHOTOMETRICAL AND IMMUNOHISTOCHEMISTRICAL RESEARCH OF RENAL INTRATUBULAR NEOPLASIA IN PERITUMOUROUS ZONE OF A RENAL CARCINOMA
https://doi.org/10.17650/1726-9776-2012-8-3-19-23
Abstract
In this work displays renal intratubular neoplasia (RIN) in peritumourous zone of a renal carcinoma have been studied. The object of our work, are the operative materials of 42 patients. Middle age of patients has made 57,4 ± 1,4 year. Men was 25, women — 17. Characteristic of tubular epithelium in PZ a renal carcinoma have been studied morphofunctional by means of histological, histospectrophotometrical and immunohistochemistrical methods. It is shown, that in PZ tumors of a high degree displays, of RIN much more often, than in tumors of low degree anaplasia. In tumors of a high degree anaplasia in tubular epithelium PZ registered increasing of nucleus, ploidy and expression of AgNORs, Ki-67, p53 and bcl-2. The presence of displays RIN in tubular epithelium PZ at a renal carcinoma should be considered at surgery operations.
About the Authors
T. M. Cherdantseva
The Altay state of medical university; The Altay branch GU «The Russian oncological centre of N.N. Blohina» of the Russian Academy of Medical Science, Barnaul
Russian Federation
Russian Federation
I. P. Bobrov
The Altay state of medical university; The Altay branch GU «The Russian oncological centre of N.N. Blohina» of the Russian Academy of Medical Science, Barnaul
Russian Federation
Russian Federation
V. V. Klimachev
The Altay state of medical university; The Altay branch GU «The Russian oncological centre of N.N. Blohina» of the Russian Academy of Medical Science, Barnaul
Russian Federation
Russian Federation
V. M. Brjuhanov
The Altay state of medical university; The Altay branch GU «The Russian oncological centre of N.N. Blohina» of the Russian Academy of Medical Science, Barnaul
Russian Federation
Russian Federation
A. F. Lazarev
The Altay state of medical university; The Altay branch GU «The Russian oncological centre of N.N. Blohina» of the Russian Academy of Medical Science, Barnaul
Russian Federation
Russian Federation
A. M. Avdalyan
The Altay state of medical university; The Altay branch GU «The Russian oncological centre of N.N. Blohina» of the Russian Academy of Medical Science, Barnaul
Russian Federation
Russian Federation
V. Ya. Gervald
The Altay state of medical university; The Altay branch GU «The Russian oncological centre of N.N. Blohina» of the Russian Academy of Medical Science, Barnaul
Russian Federation
Russian Federation
E. I. Sechenev
The Altay state of medical university; The Altay branch GU «The Russian oncological centre of N.N. Blohina» of the Russian Academy of Medical Science, Barnaul
Russian Federation
Russian Federation
References
1. Непомнящий В.М., Романенко А.М., Данилец Р.О. Ренальная интратубулярная неоплазия — предрак? Материалы I конгресса Российского общества онкоурологов. Москва, 4−5 октября, 2006. С. 156−157. Mourad W.A., Nestok B.R., Saleg G.Y. et al. Dysplastic tubular epithelium in «normal» kidney associated with renal cell carcinoma. Am J Surg Pathol 1994;18:1117−24.
2. Yorukoglu O.K., Aktas S., Mungan S.U., Kirkali Z. Tubular dysplasia and carcinoma in situ: precursor of renal cell carcinoma. Urol 1999;53:684−9.
3. Kennedy S., Merino M., Lineham W. et al. Collecting duct carcinoma of the kidney. Hum Pathol 1990;21:449−53.
4. Романенко А.М. Иммуногистохимическая диагностика опухолей почек. Руководство по иммуногистохимической диагностике опухолей человека. Под ред. С.В. Петрова и Н.Т. Райхлина. 2004.
5. Романенко А.М., Возианов А.М., Непомнящий В.М. и др. Реальная интратубулярная неоплазия как предрак почки. Урология 2003;(4):4−9.
6. Fuhrman S.A., Lasky L.C., Limas C. Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol 1982;6:655−63.
7. Daskal Y., Smetana K., Buch H. Evedence from studies on segregated that nucleolar silver proteins C23 and B23 are in fibrillar components. Exp Cell Res 1980;127:285−91.
8. Бобров И.П., Авдалян А.М., Климачев В.В. и др. Модификация гистохимического метода выявления ядрышковых организаторов на гистологических срезах. Арх патол 2010; (3):35−7.
Review
For citations:
Cherdantseva T.M., Bobrov I.P., Klimachev V.V., Brjuhanov V.M., Lazarev A.F., Avdalyan A.M., Gervald V.Ya., Sechenev E.I. HISTOSPECTROPHOTOMETRICAL AND IMMUNOHISTOCHEMISTRICAL RESEARCH OF RENAL INTRATUBULAR NEOPLASIA IN PERITUMOUROUS ZONE OF A RENAL CARCINOMA. Cancer Urology. 2012;8(3):19-23. (In Russ.) https://doi.org/10.17650/1726-9776-2012-8-3-19-23
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