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COMPARATIVE ANALYSIS OF THE BACTERIAL POPULATION OF THE PROSTATE IN ITS CANCER AND BENIGN HYPERPLASIA

https://doi.org/10.17650/1726-9776-2011-7-3-95-99

Abstract

A bacteriological study of prostate biopsy specimens was conducted in patients with prostate benign hyperplasia (PBH) and in those with prostate cancer (PC). It revealed a wide range of aerobic (Corynebacterium sp., Enterococcus sp., E. coli, S. haemolyticus, S. hominis) and nonclostridial anaerobic (Bacteroides sp., Bifidobacterium sp., Eubacterium sp., Propionibacterium sp., Рeptococcus niger, Peptostreptococcus sp., Prevotella sp., Veilonella sp., Fusobacterium sp., Capnocytophaga ochracea, Streptococcus parvulus) bacteria. Differences were seen in the detection rate of these microorganisms and in the level of tissue infectivity in PBH and PC. The average seeding of the prostate biopsy specimens and the detection rate of different types of bacteria in PBH were greater than those in PC; moreover, some bacteria were undetectable in PC at all.

About the Authors

M. I. Kogan
Research Institute of Urology and Nephrology
Russian Federation


Yu. L. Naboka
Department of Microbiology and Virology, Rostov State Medical University; Rostov-on-Don
Russian Federation


L. I. Vasilyeva
Department of Microbiology and Virology, Rostov State Medical University; Rostov-on-Don
Russian Federation


M. B. Chibichyan
Research Institute of Urology and Nephrology
Russian Federation


A. V. Ilyash
Research Institute of Urology and Nephrology
Russian Federation


O. N. Vasilyev
Research Institute of Urology and Nephrology
Russian Federation


References

1. Fibbi B., Penna G., Morelli A. et al. Chronic inflammation in the pathogenesis of benign prostatic hyperplasia.Int J Androl 2010; 33(3):475−88.

2. Lucia M.S., Lambert J.R. Growth factors in benign prostatic hyperplasia: basic science implications. Curr Urol Rep 2008; 9(4):272−8.

3. Robert G., Descazeaud A., Nicolaïew N.et al. Inflammation in benign prostatic hyperplasia: a 282 patients' immunohistochemical analysis.Prostate 2009; 69(16):1774−80.

4. Kwon Y.K., Choe M.S., Seo K.W.et al. The effect of intraprostatic chronic inflammation on benign prostatic hyperplasia treatment. Korean J Urol 2010;51(4):266−70.

5. Sciarra A., Di Silverio F., Salciccia S.et al. Inflammation and chronic prostatic diseases: evidence for a link?EurUrol 2007; 2(4):964−72.

6. Sciarra A., Mariotti G., Salciccia S. et al. Prostate growth and inflammation. J Steroid Biochem Mol Biol 2008; 108(3−5):254−60.

7. Аляев Ю.Г., Винаров А.З., Фиев Д.Н. и др. Возможно ли влияние микоплазменной инфекции на патогенез рака предстательной железы. Онкоурология 2010; (1):28−32.

8. Sugar L.M. Inflammation and prostate cancer. Can J Urol 2006;13Suppl 1:46−7. 9. Palapattu G.S., Sutcliffe S., Bastian P.J.et al. Prostate carcinogenesis and inflammation: emerging insights. Carcinogenesis 2005;26(7):1170−81.

9. Bastian P.J., Nuhn P., Stadler T.C. et al. Prostatic inflammation and prostate cancer Urologe A 2010; 49(5):636−8.

10. Namiki K., Goodison S., Porvasnik S. et аl. Persistent exposure to mycoplasma induces malignant transformation of human prostate cellsPLoS One. 2009;4 (9): e6872.

11. Elizabeth A. Platz, Angelo M. De Marzo. Epidemiology of inflammation and prostate cancer. J Urol 2004;171(2):36−40.

12. Cohen R.J., Shannon B.A., McNeal J.E.et al. Propionibacterium acnes associated with inflammation in radical prostatectomy specimens: a possible link to cancer evolution? J Urol 2005;173(6):1969−74.

13. Sfanos K.S., Sauvageot J., Fedor H.L. et al. A molecular analysis of prokaryotic and viral DNA sequences in prostate tissue from patients with prostate cancer indicates the presence of multiple and diverse microorganisms. Prostate 2008;68(3):306−20.

14. Keay S., Zhang C.O., Baldwin B.R. et al. Polymerase chain reaction amplification of bacterial 16s rRNA genes in prostate biopsies from men without chronic prostatitis. Urology 1999;53(3):487−91.

15. Krieger J.N., Riley D.E., Vesella R.L. et al. Bacterial dna sequences in prostate tissue from patients with prostate cancer and chronic prostatitis. J Urol 2000; 164(4):1221−8.

16. Alexeyev O., Bergh J., Marklund I. et al. Association between the presence of bacterial 16S RNA in prostate specimens taken during transurethral resection of prostate and subsequent risk of prostate cancer (Sweden).Cancer Causes Control 2006; 17(9):1127−33.


Review

For citations:


Kogan M.I., Naboka Yu.L., Vasilyeva L.I., Chibichyan M.B., Ilyash A.V., Vasilyev O.N. COMPARATIVE ANALYSIS OF THE BACTERIAL POPULATION OF THE PROSTATE IN ITS CANCER AND BENIGN HYPERPLASIA. Cancer Urology. 2011;7(3):95-99. (In Russ.) https://doi.org/10.17650/1726-9776-2011-7-3-95-99

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ISSN 1726-9776 (Print)
ISSN 1996-1812 (Online)
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