КАРТИРОВАНИЕ ПРОТЕОМА ПЛАЗМЫ КРОВИ ЧЕЛОВЕКА В НОРМЕ И ПРИ СВЕТЛОКЛЕТОЧНОМ РАКЕ ПОЧКИ
Аннотация
Проведено масс-спектрометрическое картирование протеома плазмы крови больных почечно-клеточным раком (ПКР) и конт-рольной группы. Идентифицировано 247 белков, из них экспрессия 12 белков увеличивалась при переходе от данных контрольной группы к анализам больным с I−II и III−IV стадиями заболевания. Снижение экспрессии в этом ряду показывали 14 белков. Из 26 протеинов, показавших изменение экспрессии, 7 относятся к белкам острой фазы, 3 белка связаны с межклеточным матриксом. Данные белки могут быть потенциальными маркерами ПКР.
Об авторах
В. Е. Шевченко
РОНЦ им. Н.Н. Блохина РАМН, Москва
Россия
Россия
С. В. Ковалев
РОНЦ им. Н.Н. Блохина РАМН, Москва
Россия
Россия
В. А. Юрченко
РОНЦ им. Н.Н. Блохина РАМН, Москва
Россия
Россия
В. Б. Матвеев
РОНЦ им. Н.Н. Блохина РАМН, Москва
Россия
Россия
Д. Г. Заридзе
РОНЦ им. Н.Н. Блохина РАМН, Москва
Россия
Россия
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Для цитирования:
Шевченко В.Е., Ковалев С.В., Юрченко В.А., Матвеев В.Б., Заридзе Д.Г. КАРТИРОВАНИЕ ПРОТЕОМА ПЛАЗМЫ КРОВИ ЧЕЛОВЕКА В НОРМЕ И ПРИ СВЕТЛОКЛЕТОЧНОМ РАКЕ ПОЧКИ. Онкоурология. 2011;7(3):65-69. https://doi.org/10.17650/1726-9776-2011-7-3-65-69
For citation:
Shevchenko V.E., Kovalev S.V., Yurchenko V.A., Matveev V.B., Zaridze D.G. HUMAN PLASMA PROTEOME MAPPING IN HEALTH AND CLEAR CELL CARCINOMA OF THE KIDNEY. Cancer Urology. 2011;7(3):65-69. (In Russ.) https://doi.org/10.17650/1726-9776-2011-7-3-65-69
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