Ewing sarcoma: Clinical case and literature review
https://doi.org/10.17650/1726-9776-2025-21-2-138-144
Abstract
This article presents a clinical case of treatment of a female patient with Ewing Sarcoma of the kidney. Currently, treatment standards haven’t yet been developed due to the rarity of this pathology. We describe our own experience of drug treatment of Ewing sarcoma of the kidney recurrence after surgery.
About the Authors
A. K. ZarenkovaRussian Federation
Anastasiya Konstantinovna Zarenkova
24 Kashirskoe Shosse, Moscow 115522
F. I. Salimzyanov
Russian Federation
24 Kashirskoe Shosse, Moscow 115522
M. E. Abramov
Russian Federation
24 Kashirskoe Shosse, Moscow 115522
M. S. Gileva
Russian Federation
24 Kashirskoe Shosse, Moscow 115522
K. A. Firsov
Russian Federation
24 Kashirskoe Shosse, Moscow 115522
A. A. Rumyantsev
Russian Federation
24 Kashirskoe Shosse, Moscow 115522
References
1. Seemayer T.A., Thelmo W.L., Bolande R.P. et al. Peripheral neuroectodermal tumors. Perspect Pediatr Pathol. 1975;2:151–72. PMID: 1129029.
2. Bing Z., Zhang P., Tomaszewski J.E. et al. Primary Ewing sarcoma/ primitive neuroectodermal tumor of the kidney. J Urol 2009;181(3):1341–2. DOI: 10.1016/j.juro.2008.12.029
3. Strauss S.J., Frezza A.M., Abecassis N. et al. Bone sarcomas: ESMO-EURACAN-GENTURIS-ERN PaedCan Clinical Practice Guideline for diagnosis, treatment and follow-up. Ann Oncol 2021;32(12):1520–36. DOI: 10.1016/j.annonc.2021.08.1995
4. Geens L., Robays J.V., Geert V. et al. An unusual location of extraosseous Ewing’s sarcoma. Case Rep Oncol 2013;6(2): 293–302. DOI: 10.1159/000351836
5. Xiao Y., Zhi Y., Cao G. et al. Primary Ewing’s sarcoma of the uterine cervix: a case report and review of the literature. J Cancer Res Clin Oncol 2024;150(5):267. DOI: 10.1007/s00432-024-05698-2
6. Krouma M., Farah K., Choucha A. et al. Primary intradural Extraosseous Ewing’s sarcoma of the cauda equina: a case report and literature review. Neurochirurgie 2024;70(4):101562. DOI: 10.1016/j.neuchi.2024.101562
7. Juan L., Jianqun Y., Fanglan L. Rare origin – Ewing’s sarcoma of the pleura: a case report and literature review. J Radiol Case Rep 2023;17(10):21–5. DOI: 10.3941/jrcr.v17i8.5187
8. Rachapudi S., Srinivasan A., Gorman B. et al. Ewing’s sarcoma of the male external genitalia: a case report and review of the literature. BMC Urol 2022;22(1):121. DOI: 10.1186/s12894-022-01072-x
9. Sethi P., Singh A., Srinivas B.H. et al. Practical approach in management of extraosseous Ewing’s sarcoma of head and neck: a case series and review of literature. Gulf J Oncolog 2022;1(39):79–88. PMID: 35695350.
10. Cheng L., Xu Y., Song H. et al. A rare entity of primary Ewing sarcoma in kidney. BMC Surg 2020;20(1):280. DOI: 10.1186/s12893-020-00948-9
11. Esiashvili N., Goodman M., Marcus R.B. Jr. Changes in incidence and survival of Ewing sarcoma patients over the past 3 decades: surveillance epidemiology and end results data. J Pediatr Hematol Oncol 2008;30(6):425–30. DOI: 10.1097/MPH.0b013e31816e22f3
12. Tarek N., Said R., Andersen C.R. et al. Primary Ewing sarcoma/ primitive neuroectodermal tumor of the kidney: the MD Anderson Cancer Center experience. Cancers (Basel) 2020;12(10):2927. DOI: 10.3390/cancers12102927
13. Risi E., Iacovelli R., Altavilla A. et al. Clinical and pathological features of primary neuroectodermal tumor/Ewing sarcoma of the kidney. Urology 2013;82(2):382–6. DOI: 10.1016/j.urology.2013.04.015
14. Lalwani N., Prasad S.R., Vikram R. et al. Pediatric and adult primary sarcomas of the kidney: a cross-sectional imaging review. Acta Radiol 2011;52(4):448–57. DOI: 10.1258/ar.2011.100376
15. Rossi S., Orvieto E., Furlanetto A. et al. Utility of the immunohistochemical detection of FLI-1 expression in round cell and vascular neoplasm using a monoclonal antibody. Mod Pathol 2004;17(5):547–52. DOI: 10.1038/modpathol.3800065
16. Sorensen P.H., Lessnick S.L., Lopez-Terrada D. et al. A second Ewing’s sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG. Nat Genet 1994;6(2):146–51. DOI: 10.1038/ng0294-146
17. Galyfos G., Karantzikos G.A., Kavouras N. et al. Extraosseous Ewing sarcoma: diagnosis, prognosis and optimal management. Indian J Surg 2016;78(1):49–53. DOI: 10.1007/s12262-015-1399-0
18. Das S., Aggarwal G., Gupta S. et al. Primary renal Ewing’s sarcoma in an adult: an enigma. Innov Surg Sci 2021;6(1):20200022. DOI: 10.1515/iss-2020-0022
19. Kuczynski A.P., Gugelmin E.S., Netto R.A. Tumor primitivo neuroectodérmico de rim em criança [Primitive neuroectodermal tumor of the kidney in children]. J Pediatr (Rio J) 2001;77(1):49–51. DOI: 10.2223/jped.111
20. Jimenez R.E., Folpe A.L., Lapham R.L. et al. Primary Ewing’s sarcoma/ primitive neuroectodermal tumor of the kidney: a clinicopathologic and immunohistochemical analysis of 11 cases. Am J Surg Pathol 2002;26(3):320–7. DOI: 10.1097/00000478-200203000-00005
21. Bradford K., Nobori A., Johnson B. et al. Primary renal Ewing sarcoma in children and young adults. J Pediatr Hematol Oncol 2020;42(8):474–81. DOI: 10.1097/MPH.0000000000001804
22. Abboud A., Masrouha K., Saliba M. et al. Extraskeletal Ewing sarcoma: diagnosis, management and prognosis. Oncol Lett 2021;21(5):354. DOI: 10.3892/ol.2021.12615
23. Krasin M.J., Davidoff A.M., Rodriguez-Galindo C. et al. Definitive surgery and multiagent systemic therapy for patients with localized Ewing sarcoma family of tumors: local outcome and prognostic factors. Cancer 2005;104(2):367–73. DOI: 10.1002/cncr.21160
24. Krasin M.J., Rodriguez-Galindo C., Davidoff A.M. et al. Efficacy of combined surgery and irradiation for localized Ewings sarcoma family of tumors. Pediatr Blood Cancer 2004;43(3):229–36. DOI: 10.1002/pbc.20095
25. Laskar S., Sinha S., Chatterjee A. et al. Radiation therapy dose escalation in unresectable Ewing sarcoma: final results of a phase 3 randomized controlled trial. Int J Radiat Oncol Biol Phys 2022;113(5):996–1002. DOI: 10.1016/j.ijrobp.2022.04.024
26. El Weshi A., Allam A., Ajarim D. et al. Extraskeletal Ewing’s sarcoma family of tumours in adults: analysis of 57 patients from a single institution. Clin Oncol (R Coll Radiol) 2010;22(5):374–81. DOI: 10.1016/j.clon.2010.02.010
27. Grier H.E., Krailo M.D., Tarbell N.J. et al. Addition of ifosfamide and etoposide to standard chemotherapy for Ewing’s sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med 2003;348(8):694–701. DOI: 10.1056/NEJMoa020890
28. Le Deley M.C., Paulussen M., Lewis I. et al. Cyclophosphamide compared with ifosfamide in consolidation treatment of standard-risk Ewing sarcoma: results of the randomized noninferiority Euro-EWING99-R1 trial. J Clin Oncol 2014;32(23):2440–8. DOI: 10.1200/JCO.2013.54.4833
Review
For citations:
Zarenkova A.K., Salimzyanov F.I., Abramov M.E., Gileva M.S., Firsov K.A., Rumyantsev A.A. Ewing sarcoma: Clinical case and literature review. Cancer Urology. 2025;21(2):138-144. (In Russ.) https://doi.org/10.17650/1726-9776-2025-21-2-138-144