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Transarterial embolization of renal cell carcinoma (modern review)

https://doi.org/10.17650/1726-9776-2024-20-3-152-158

Abstract

Currently, renal cell carcinoma is one of the most common malignant neoplasms, the main treatment method of which is surgery. However, surgical treatment in some cases may be accompanied by deterioration of renal function, which dictates the need to search for alternative treatment methods. This review examines the possibilities of a minimally invasive, radiosurgical procedure – transarterial embolization of the renal arteries in the treatment of renal cell carcinoma. Options for performing this procedure and indications for them are given, the results of using transarterial embolization of the renal arteries for renal cell carcinoma are analyzed, and possible complications are described. The advantages of the method are indicated. The need for further large-scale scientific research devoted to studying the effectiveness and safety of transarterial embolization of the renal artery for renal cell carcinoma is urgent.

About the Authors

S. V. Popov
St. Luka’s Clinical Hospital; Saint Petersburg Medical-Social Institute; S.M. Kirov Military Medical Academy, Ministry of Defense of Russia
Russian Federation

46 Chugunnaya St., Saint Petersburg 194044,

Lit. A, 72 Kondratyevskiy Prospekt, Saint Petersburg 195271,

37 Akademika Lebedeva St., Saint Petersburg 194044



R. G. Guseynov
St. Luka’s Clinical Hospital; Saint Petersburg Medical-Social Institute; Saint Petersburg State University
Russian Federation

Ruslan G. Guseynov 

46 Chugunnaya St., Saint Petersburg 194044,

7–9 Universitetskaya Naberezhnaya, Saint Petersburg 199034



S. G. Vintskovskiy
St. Luka’s Clinical Hospital
Russian Federation

46 Chugunnaya St., Saint Petersburg 194044



A. V. Alkhazishvili
St. Luka’s Clinical Hospital
Russian Federation

46 Chugunnaya St., Saint Petersburg 194044



K. V. Sivak
St. Luka’s Clinical Hospital
Russian Federation

46 Chugunnaya St., Saint Petersburg 194044



V. V. Perepelitsa
St. Luka’s Clinical Hospital; Saint Petersburg Medical-Social Institute
Russian Federation

46 Chugunnaya St., Saint Petersburg 194044,

Lit. A, 72 Kondratyevskiy Prospekt, Saint Petersburg 195271



R. O. Grushevskiy
St. Luka’s Clinical Hospital
Russian Federation

46 Chugunnaya St., Saint Petersburg 194044



I. O. Shmidt
St. Luka’s Clinical Hospital
Russian Federation

46 Chugunnaya St., Saint Petersburg 194044



N. S. Bunenkov
St. Luka’s Clinical Hospital; I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia; V.A. Almazov National Medical Research Centre, Ministry of Health of Russia
Russian Federation

46 Chugunnaya St., Saint Petersburg 194044,

6–8 L’va Tolstogo St., Saint Petersburg 197022,

2 Akkuratova St., Saint Petersburg 197341



T. A. Lelyavina
St. Luka’s Clinical Hospital
Russian Federation

46 Chugunnaya St., Saint Petersburg 194044



References

1. Bray F., Ferlay J., Soerjomataram I. et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018;68(6):394–424. DOI: 10.3322/caac.21492

2. Bahadoram S., Davoodi M., Hassanzadeh S. et al. Renal cell carcinoma: an overview of the epidemiology, diagnosis, and treatment. G Ital Nefrol 2022;39(3):2022−vol3.

3. Medina-Rico M., Ramos H.L., Lobo M. et al. Epidemiology of renal cancer in developing countries: review of the literature. Can Urol Assoc J 2018;12(3):154−62. DOI: 10.5489/cuaj.4464

4. Vasudev N.S., Wilson M., Stewart G.D. et al. Challenges of early renal cancer detection: symptom patterns and incidental diagnosis rate in a multicentre prospective UK cohort of patients presenting with suspected renal cancer. BMJ 2020;10(5):e035938. DOI: 10.1136/bmjopen-2019-035938

5. State of oncological care in Russia in 2021. Eds.: А.D. Kaprin, V.V. Starinskiy, A.O. Shachzadova. Moscow: MNIOI im. P.A. Gertsena – filial FGBU “NMITS radiologii” Minzdrava Rossii, 2022. 239 p. (In Russ.).

6. Escudier B., Porta C., Schmidinger M. et al. Renal cell carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2019;30(5):706−20. DOI: 10.1093/annonc/mdz056

7. Lee M., Wang Q., Wanchoo R. et al. Chronic kidney disease in cancer survivors. Adv Chronic Kidney Dis 2021;28(5):469−76.e1. DOI: 10.1053/j.ackd.2021.10.007

8. Wood A.M., Benidir T., Campbell R.A. et al. Long-term renal function following renal cancer surgery: historical perspectives, current status, and future considerations. Urol Clin North Am 2023;50(2):239−59. DOI: 10.1016/j.ucl.2023.01.004

9. Hora M., Eret V., Trávníček I. et al. Surgical treatment of kidney tumors – contemporary trends in clinical practice. Cent European J Urol 2016;69(4):341−6. DOI: 10.5173/ceju.2016.845

10. Cho S., Kang S.H. Current status of cryotherapy for prostate and kidney cancer. Korean J Urol 2014;55(12):780−8. DOI: 10.4111/kju.2014.55.12.780

11. Lalli A.F., Peterson N., Bookstein J.J. Roentgen-guided infarctions of kidneys and lungs. A potential therapeutic technic. Radiology 1969;93(2):434−5. DOI: 10.1148/93.2.434

12. Almgård L.E., Fernström I., Haverling M., Ljungqvist A. Treatment of renal adenocarcinoma by embolic occlusion of the renal circulation. Br J Urol 1973;45(5):474−9. DOI: 10.1111/j.1464-410x.1973.tb06806.x

13. Melchiorre F., Patella F., Pescatori L. et al. DEB-TACE: a standard review. Fut Oncol 2018;14(28):2969−84. DOI: 10.2217/fon-2018-0136

14. Gao X., Chen Z., Chen Z. et al. Visualization and evaluation of chemoembolization on a 3D decellularized organ scaffold. ACS Biomater Sci Eng 2021;7(12):5642−53. DOI: 10.1021/acsbiomaterials.1c01005

15. Jonasch E. Updates to the management of kidney cancer. J Natl Compr Canc Netw 2018;16(5S):639−41. DOI: 10.6004/jnccn.2018.0039

16. Dabestani S., Marconi L., Kuusk T., Bex A. Follow-up after curative treatment of localised renal cell carcinoma. World J Urol 2018;36(12):1953−9. DOI: 10.1007/s00345-018-2338-z

17. Reitz M., Mende K.C., Cramer C. et al. Surgical treatment of spinal metastases from renal cell carcinoma-effects of preoperative embolization on intraoperative blood loss. Neurosurgical Rev 2018;41:861−7. DOI: 10.1007/s10143-017-0935-8

18. Ratasvuori M., Sillanpää N., Wedin R. et al. Surgery of non-spinal skeletal metastases in renal cell carcinoma: No effect of preoperative embolization? Acta Orthopaedica 2016;87:183−8. DOI: 10.3109/17453674.2015.1127726

19. Mohakud S., Tripathy S., Bag N.D., Mishra N. Multidisciplinary management of solitary hypervascular metastatic recurrence of renal cell carcinoma presenting with pathological femoral fracture. BMJ Case Rep 2021;14(11):e245422. DOI: 10.1136/bcr-2021-245422

20. Zielinski H., Syrylo T., Szmigielski S. Renal artery embolization in treatment of renal cancer with emphasis on response of immune system. In: Jindong Chen (editor) Renal Tumor. London: IntechOpen; 2013. Available at: https://www.intechopen.com/ chapters/42633. DOI: 10.5772/54116

21. Syrylo T. Influence of renal artery embolization on efficacy of immune system in patients with renal cancer [In Polish]. D.M.Sc. thesis. Military Institute of Medicine, Warsaw, Poland, 2012. 90 p.

22. Bouvier A., Besnier L., Paisant A. et al. Blue dye embolization of renal tumor: a new technique to improve tumor localization during laparoscopic partial nephrectomy. J Laparoendosc Adv Surg Tech A 2020;30(3):299−303. DOI: 10.1089/lap.2019.0686

23. Maksimov A.V., Martov A.G., Ivanov P.M. et al. Safety of superselective balloon embolization of the segmental renal artery during partial nephrectomy. Eksperimental’naya i klinicheskaya urologiya = Experimental and Clinical Urology 2019;(3):79−83. (In Russ.).

24. Maksimov A.V., Ivanov P.M., Ivanova F.G., Neustroev P.A. Anti-relapse targeted chemoembolization as an adjunct to kidney cancer resection. Yakutskiy meditsinskiy zhurnal = Yakutsk Medical Journal 2021;(1):33–6. (In Russ.).

25. Karalli A., Ghaffarpour R., Axelsson R. et al. Transarterial chemoembolization of renal cell carcinoma: a prospective controlled trial. J Vasc Interv Radiol 2017;28(12):1664–72. DOI: 10.1016/j.jvir.2017.08.001

26. Karpov V.K., Kamalov D.M., Shaparov B.M. et al. Superselective renal artery embolization as monotherapy for kidney cancer in a patient with high anesthetic risk. Khirurgicheskaya praktika 2021;(4):61–7. (In Russ.). DOI: 10.38181/2223-2427-2021-4-61-67

27. Wright B., Johnson B.S., Vassar M. et al. Trans-arterial embolization of renal cell carcinoma: a systematic review and meta-analysis. Abdom Radiol (NY) 2022;47(6):2238–43. DOI: 10.1007/s00261-022-03502-8

28. Bi Y., Shi X., Ren J. et al. Transarterial chemoembolization of unresectable renal cell carcinoma with doxorubicin-loaded CalliSpheres drug-eluting beads. Sci Rep 2022;12(1):8136. DOI: 10.1038/s41598-022-12334-x

29. Andreev S.S., Tityaev I.I., Neimark B.A., Vasilenko A.A. Early signs of dysfunction of a single kidney after nephrectomy for kidney cancer. Ural’skiy meditsinskiy zhurnal = Ural Medical Journal 2022;21(4):13–8. (In Russ.).

30. Astashov V.L., Shapovalov V.V., Balanyuk V.V. et al. First experience of superselective embolization of renal arteries supplying the tumor with subsequent laparoscopic kidney resection. Onkourologiya = Cancer Urology 2021;17(3):30–6. (In Russ.). DOI: 10.17650/1726-9776-2021-17-3-30-36.

31. Tsuji Y., Miura H., Hirota T. et al. Transarterial ethiodised oil marking before CT-guided renal cryoablation: evaluation of tumour visibility in various renal cell carcinoma subtypes. Clin Radiol 2023;78(4):279–85. DOI: 10.1016/j.crad.2022.12.010

32. Gunn A.J., Patel A.R., Rais-Bahrami S. Role of angioembolization for renal cell carcinoma. Curr Urol Rep 2018;19(10):76. DOI: 10.1007/s11934-018-0827-7

33. Bravi C.A., Vertosick E., Benfante N. et al. Impact of acute kidney injury and its duration on long-term renal function after partial nephrectomy. Eur Urol 2019;76(3):398–403. DOI: 10.1016/j.eururo.2019.04.040

34. Çelebioğlu E.C., Bilgiç S., Merter A. et al. Scheduling surgery after transarterial embolization: does timing make any difference to intraoperative blood loss for renal cell carcinoma bone metastases? Diagn Interv Radiol 2021;27(6):740–5. DOI: 10.5152/dir.2021.21011

35. Kato S., Hozumi T., Takaki Y. et al. Optimal schedule of preoperative embolization for spinal metastasis surgery. Spine (Phila Pa 1976) 2013;38(22):1964–9. DOI: 10.1097/BRS.0b013e3182a46576

36. Koob S., Schulze-Steinen H., Plöger M.M. et al. Preoperative embolization of renal cell carcinoma metastases to the bone prior to stabilization procedures does not result in reduction in intraoperative blood loss. Clin Exp Metastasis 2023;40(1):117–22. DOI: 10.1007/s10585-022-10195-2

37. Wessendorf J., König A.M., Heers H., Mahnken A.H. Efficacy and safety of combined embolization and radiofrequency ablation in stage 1 renal cell carcinomas. Rofo 2022;194(9):1020–5. DOI: 10.1055/a-1770-4724

38. Salei A., Raymond M., Savage C. et al. Transarterial embolization of T1b and T2a renal cell carcinoma prior to percutaneous cryoablation: a retrospective comparative study. Abdom Radiol (NY) 2023;48(2):773–9. DOI: 10.1007/s00261-022-03755-3

39. Sommer C.M., Pallwein-Prettner L., Vollherbst D.F. et al. Transarterial embolization (TAE) as add-on to percutaneous radiofrequency ablation (RFA) for the treatment of renal tumors: Review of the literature, overview of state-of-the-art embolization materials and further perspective of advanced image-guided tumor ablation. Eur J Radiol 2017;86:143–62. DOI: 10.1016/j.ejrad.2016.10.024

40. Kobe A., Tselikas L., Deschamps F. et al. Thermal ablation combined with selective transarterial embolization of centrally located renal cell carcinomas measuring 3 cm or larger. Cardiovasc Intervent Radiol 2022;45(3):371–9. DOI: 10.1007/s00270-021-03036-4

41. LaRussa S., Vanden Berg R.W., Craig K.M. et al. Is there a role for combination, single-session selective transarterial embolization and microwave ablation for large renal masses? Cardiovasc Intervent Radiol 2020;43(10):1468–73. DOI: 10.1007/s00270-020-02568-5

42. Gantsev Sh.H., Yun V., Zhumagulova A.K. et al. Renal artery embolization in the combined treatment of patients with stage IV kidney cancer. Kreativnaya khirurgiya i onkologiya = Creative Surgery and Oncology 2020;10(3):205–11. (In Russ.). DOI: 10.24060/2076-3093-10-3-205-211


Review

For citations:


Popov S.V., Guseynov R.G., Vintskovskiy S.G., Alkhazishvili A.V., Sivak K.V., Perepelitsa V.V., Grushevskiy R.O., Shmidt I.O., Bunenkov N.S., Lelyavina T.A. Transarterial embolization of renal cell carcinoma (modern review). Cancer Urology. 2024;20(3):152-158. (In Russ.) https://doi.org/10.17650/1726-9776-2024-20-3-152-158

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ISSN 1726-9776 (Print)
ISSN 1996-1812 (Online)
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