PROGNOSTIC FACTORS OF BIOCHEMICAL RELAPSE FREE SURVIVAL FOLLOWING SALVAGE RADIOTHERAPY IN MEN WITH BIOCHEMICAL RECURRENCE AFTER RADICAL PROSTATECTOMY
https://doi.org/10.17650/1726-9776-2013-9-3-64-69
Abstract
Purpose. To evaluate influence of clinical, biochemical and histological factors to biochemical relapse free survival (BRFS) following salvage radiotherapy (RT) in men with biochemical recurrence after radical prostatectomy.
Material and methods. 77 patients with newly diagnosed biochemical recurrence (BR) after RPE were included into retrospective study. All of them underwent local salvage RT. Сlinical variables (age, serum prostate-specific antigen [PSA] level and PSA kinetics, time RPE-BR, Gleason grade, stage after RPE and clinical findings) were evaluated using Cox proportional hazards regression analysis.
Results. The median, 1- and 3-year BRFS were 19,9 months, 63,8 ± 6,5 % and 24,7 ± 8,5 % respectively. Significant variables in the multivariable model were age, PSA level before RT, prostatectomy T3b stage, PSA doubling time and positive digital rectal examination findings (p < 0,05). Several clinical parameters help predict the outcomes of men with PSA elevation after radical prostatectomy. These data may be useful in counseling men regarding the timing of administration of adjuvant therapies.
About the Authors
P. D. Demeshko
N.N. Alexandrov National Cancer Center of Belarus, Minsk
Belarus
Belarus
O. G. Sukonko
N.N. Alexandrov National Cancer Center of Belarus, Minsk
Belarus
Belarus
S. A. Krasny
N.N. Alexandrov National Cancer Center of Belarus, Minsk
Belarus
Belarus
V. A. Suslova
N.N. Alexandrov National Cancer Center of Belarus, Minsk
Belarus
Belarus
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Review
For citations:
Demeshko P.D., Sukonko O.G., Krasny S.A., Suslova V.A. PROGNOSTIC FACTORS OF BIOCHEMICAL RELAPSE FREE SURVIVAL FOLLOWING SALVAGE RADIOTHERAPY IN MEN WITH BIOCHEMICAL RECURRENCE AFTER RADICAL PROSTATECTOMY. Cancer Urology. 2013;9(3):64-69. (In Russ.) https://doi.org/10.17650/1726-9776-2013-9-3-64-69
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