Vol 5, No 1 (2009)

Cover Page

REVIEW

РЕТЕНЦИОННЫЕ ОСЛОЖНЕНИЯ СО СТОРОНЫ ВЕРХНИХ МОЧЕВЫХ ПУТЕЙ У БОЛЬНЫХ РАКОМ ШЕЙКИ МАТКИ IIB—III СТАДИИ

., ., ., ., .

Abstract

Ретенционные осложнения  со стороны верхних мочевых путей  у больных раком шейки матки IIb—III стадии

 

Cancer Urology. 2009;5(1):78-81
pages 78-81 views

DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS

IMPROVED TECHNIQUE FOR ACHIEVING HEMOSTASIS DURING NEOPLASTIC KIDNEY RESECTION

Petrov S.B., Shpilenya E.S., Kukushkin A.V., Shkarupa D.D.

Abstract

Due to the better diagnostic feasibilities of health care facilities, the proportion of patients with small renal tumors (T1a) has substantiallyincreased in recent years. In accordance with the international standards, these patients should undergo nephron-sparing surgery: neoplas-tic kidney resection. At Russian hospitals, organ-preserving treatment is not in adequate use for the technical difficulties associated withresection and for the likelihood of postoperative complications. The performed study has yielded a simple highly effective procedure ofnephrectomy in neoplasms, by using vasoselective parenchymatous sutures enhanced with polymer stripe-implants. 

 

Cancer Urology. 2009;5(1):14-19
pages 14-19 views

THE SAFETY AND TOLERABILITY OF SORAFENIB IN THE TREATMENT OF EXTENSIVE RENAL CANCER

Biryukov V.A., Karyakin O.B.

Abstract

The performed study compared the toxic effects caused by the administration of sorafenib with the manifestations that immediately accompanied extensive renal-cell carcinoma. There is evidence that Sorafenib that is a safe and well tolerable agent increases progression-freesurvival.

 

Cancer Urology. 2009;5(1):19-26
pages 19-26 views

SPARING CYSTECTOMY IN PATIENTS WITH TRANSITIONAL-CELL CARCINOMA OF THE URINARY BLADDER

Matveyev V.B., Volkova M.I., Figurin K.M., Peters M.V.

Abstract

Cancer Urology. 2009;5(1):27-31
pages 27-31 views

EXPERIENCE IN USING BIPOLAR TRANSURETHRAL RESECTION IN THE TREATMENT OF SUPERFICIAL TUMORS OF THE URINARY BLADDER

Alyaev Y.G., Rapoport L.M., Tsarichenko D.G., Kalantarov R.A., Aksenov A.V.

Abstract

The authors describe their first experience in using bipolar transurethral resection for a urinary bladder tumor. The obvious advantage of thistechnique over others suggests that in the immediate future the bipolar technology will serve as the gold standard instead of monopolar one.

Cancer Urology. 2009;5(1):32-34
pages 32-34 views

INTRAVESICULAR IMMUNOTHERAPY WITH BCG VACCINE AND INTERFERON-αα2B FOR NON-INVASIVE CARCINOMA OF THE URINARY BLADDER: RESULTS OF PROSPECTIVE RANDOMIZED STUDY

Minich A.A., Sukonko O.G., Rolevich A.A.

Abstract

Cancer Urology. 2009;5(1):34-39
pages 34-39 views

CAUSES OF RADIATION CYSTITIS IN PATIENTS AFTER RADIOTHERAPY FOR SMALL PELVIC MALIGNANCIES

Kaprin A.D., Pasov V.V., Korolev S.V., Terekhov O.V.

Abstract

Whether it is expedient and possible to effectively affect the tumors of the urinary bladder by ionizing irradiation remains urgent not onlydue to a rise in the rate of primary carcinoma at this site, but also to the late diagnosis and high incidence of recurrences after surgical andmultimodality treatment. The paper describes the causes of radiation cystitis in patients after radiotherapy for small pelvic neoplasms andconsiders the currently available methods and technologies for eliminating these causes. 

 

Cancer Urology. 2009;5(1):39-43
pages 39-43 views

PARTIAL CYSTECTOMY AS AN ALTERNATIVE TO CYSTECTOMY FOR EXTENSIVE URINARY BLADDER INVOLVEMENT BY LOCALLY ADVANCED COLORECTAL CANCER

Likhter M.S., Shelygin Y.A., Achkasov A.I.

Abstract

The volume of an operation on the urinary bladder (UB) in case of its extensive involvement due to locally advanced colorectal can-cer varies from partial cystectomy to cystectomy. The results of a morphological examination of 18 patients after pelvic exenterationdemonstrated true invasion into the urinary bladder wall only in 7 (38.9%) cases. This created preconditions for organ-preservingtreatment. Combined operations with partial cystectomy were performed in 37 patients. Pathology showed true tumor invasion intothe urinary bladder wall in 13 (35.1%) cases. The bladder volume was 55.2±17.1 ml after surgery and 175 to 360 (230±31.2) mlfollowing autohydrotraining with pharmacological support made 3 months after surgery. No patient had recurrent urinary bladderdisease. The surgical results suggest that organ-preserving treatment does not violate the oncological radicalism principles and is aserious alternative to cystectomy: Firstly, there is no need for the technically complex stage of an operation - to create a urinaryreservoir. Secondly, urination is preserved by its natural way; there are no signs of urinary incontinence, which ensures the betterquality of life. 

 

Cancer Urology. 2009;5(1):43-47
pages 43-47 views

CLINICAL SIGNIFICANCE OF 5αα-REDUCTASE AND ANDROGEN RECEPTOR GENE POLYMORPHISMS IN PROSTATE CANCER

Loran O.B., Lukyanov I.V., Tuzov D.Y., Tyulpakov A.N.

Abstract

The development of prostate cancer is inseparably linked with the effect of androgens on the fundamental prostatic intracellular processes,such as proliferation, apoptosis, which is realized through a number of second messengers. Major of them are the AR gene encoding androgenreceptors and the SRD5A2 gene encoding 5α-reductase enzyme. This paper deals with the study of the role of these genes in prostate cancer. 

 

Cancer Urology. 2009;5(1):48-52
pages 48-52 views

REHABILITATION OF PATIENTS AFTER RADICAL PROSTATECTOMY

Pavlov V.N., Zagitov A.R., Kazikhinuro A.A., Galimzyanov V.Z., Ishemgulov R.R., Mustafin A.T., Kutliyarov L.M.

Abstract

According to the data obtained by Russian and foreign investigators, the major complication after radical prostatectomy (RPE) is urinaryincontinence that is recorded in 20-30% of cases.

Objective. To improve the results of surgical treatment in patients with prostate cancer, by developing and introducing a well-rounded post-operative rehabilitation program.

Subjects and methods. Seventy-four patients who were treated at the urology clinic, Bashkir State Medical University, and underwent RPEin 2005 to 2007 have been examined; 27 of them were diagnosed as having urinary incontinence (UI). After discharge from the clinic, acontrol group received rehabilitative treatment at the sanatorium “Krasnousolsk” of the Republic of Bashkortostan.

 Results and discussion. Therapeutic exercises and pelvic floor electrostimulation halve the number of day urinations and paddings used inpatients with UI, by increasing the bladder capacity from 138.2±12.7 to 196±11.2 ml and improving the trophism of the bladder neck andurethra in the sphincteral area.

 

Cancer Urology. 2009;5(1):53-55
pages 53-55 views

COMPLEX ANALYSIS OF PROGNOSTIC FACTORS IN PATIENTS WITH ADVANCED AND LOCALLY ADVANCED PROSTATE CANCER

Vorobyev N.V., Alekseyev B.Y., Filimonov V.V., Zemlyansky A.Y.

Abstract

Cancer Urology. 2009;5(1):56-63
pages 56-63 views

ROLE OF LEUPRORELINE ACETATE DEPOT (LUCRIN DEPOT®) FORMULATIONS IN THE TREATMENT OF PROSTATE CANCER

Volkova M.I.

Abstract

Lucrin depot used to treat patients with prostate cancer has been investigated. The agent has been found to be highly effective, to causeadverse effects rarely, and to be well tolerated. The administration of leuproreline acetate yields the results comparable with those in the useof other luteining hormone-releasing hormone agonists and antagonists, bilateral orchiectomy, and estrogens. 

 

Cancer Urology. 2009;5(1):64-67
pages 64-67 views

PHARMACODYNAMIC EQUIVALENCE OF USING 3-MONTH AND 28-DAY SUSTAINED-RELEASE DECAPEPTYL DEPOT FORMULATIONS IN PATIENTS WITH ADVANCED PROSTATE CANCER

Teillac P., Heyns C.F., Kaisary A.V., Bouchot O., Blumberg J.

Abstract

Objective: to evaluate the pharmacodynamic equivalence of 3-month and 28-day formulations of tryptoreline, a sustained-release luteininghormone (LH)-releasing hormone analogue.

Subjects and methods. The patients who had a verified diagnosis of locally advanced or metastatic prostate cancer were randomized intogroups to have either one injection of a 3-month dosage form (n = 63) or 3 injections of a 28-day formulation at 28-day intervals (n = 68).The onset rate of drug-induced castration, which was defined as a percentage of the patients achieving a plasma testosterone level of ≤0.5ng/ml, was compared on day 84 (i.e. thrice every 28 days). The plasma profiles of testosterone, LH, and tryptoreline, as well as the changesin the plasma concentration of prostate-specific antigen (PCA) from the baseline values were estimated within 3 months (from the initiationof therapy to day 91).

Results. In the 3-month and 28-day groups, the onset rate of drug-induced castration was 98 and 96%, respectively (at confidenceintervals (94.2% bilaterally) in [-8.1%; 9.6%]. The median time for drug-induced castration was 18.8 and 18.5 days, respective-ly (p = 0.86; log-rank test). The ratios of the mean peak plasma concentrations to AUC91 of the two formulations for testosteroneand LH were within 0.80; 1.25 equivalence interval. By day 91, the mean PSA level was decreased by 91.0 and 91.7%, respec-tively (p = 0.73).

Conclusion. The use of the two formulations during 3 months is pharmacologically equal. 

 

Cancer Urology. 2009;5(1):68-71
pages 68-71 views

PROBLEMS IN ORGANIZATION OF HEALTH CARE SERVICE IN ONCOUROLOGICAL DISEASES

ORGANIZATION OF EARLY DIAGNOSIS OF ONCOUROLOGICAL DISEASES IN THE SVERDLOVSK REGION

Zhuravlev V.N., Bazhenov I.V., Zyryanov A.V., Borzunov I.V., Zhuravlev O.V.

Abstract

A major focus of this paper is on the organization of specialized urological treatment, by taking into account the Governor's program “Male urological health” in the Sverdlovsk Region. It also shows the great importance of financial support for early diagnosis, timely effective treatment, clinical examination, and better quality of life in the male population of the Sverdlovsk Region.

 

Cancer Urology. 2009;5(1):71-75
pages 71-75 views

DISABILITY DUE TO ONCOUROLOGICAL DISEASES

Khalyastov I.N.

Abstract

The indices of primary and repeated disability were analyzed from the materials of examining 1198 patients with oncourological diseases at the Medicosocial Examination Bureau of the Samara Region. The age-gender index and the severity of disability greatly differed in the group of persons whose disability was repeatedly established.

 

Cancer Urology. 2009;5(1):75-77
pages 75-77 views

CONGRESSES AND CONFERENCES

ОТЧЕТ О III КОНГРЕССЕ РОССИЙСКОГО ОБЩЕСТВА ОНКОУРОЛОГОВ

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Abstract

Отчет о III конгрессе Российского общества онкоурологов

Cancer Urology. 2009;5(1):82-85
pages 82-85 views

OBITUARY

ГОЦАДЗЕ ДАВИД ТОГОЕВИЧ

.

Abstract

ГОЦАДЗЕ Давид Тогоевич

 

Cancer Urology. 2009;5(1):87
pages 87 views

LECTURE

ЛЕЧЕНИЕ РЕЦИДИВОВ ГЕРМИНОГЕННЫХ ОПУХОЛЕЙ У МУЖЧИН

., ., .

Abstract

Лечение рецидивов герминогенных опухолей у мужчин

Cancer Urology. 2009;5(1):8-13
pages 8-13 views