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CLINICAL SIGNIFICANCE OF 5αα-REDUCTASE AND ANDROGEN RECEPTOR GENE POLYMORPHISMS IN PROSTATE CANCER
- Authors: Loran O.B.1, Lukyanov I.V.1, Tuzov D.Y.1, Tyulpakov A.N.2
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Affiliations:
- Department of Urology and Surgical Andrology, Russian Medical Academy of Postgraduate Education
- Department of Hereditary Endocrinopathies and Laboratory of Molecular Diagnosis, Endocrinology Research Center, Russian Agency for Health Care, Moscow
- Issue: Vol 5, No 1 (2009)
- Pages: 48-52
- Section: DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS
- Published: 30.03.2009
- URL: https://oncourology.abvpress.ru/oncur/article/view/202
- DOI: https://doi.org/10.17650/1726-9776-2009-5-1-48-52
- ID: 202
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Abstract
The development of prostate cancer is inseparably linked with the effect of androgens on the fundamental prostatic intracellular processes,such as proliferation, apoptosis, which is realized through a number of second messengers. Major of them are the AR gene encoding androgenreceptors and the SRD5A2 gene encoding 5α-reductase enzyme. This paper deals with the study of the role of these genes in prostate cancer.
About the authors
O. B. Loran
Department of Urology and Surgical Andrology, Russian Medical Academy of Postgraduate Education
Author for correspondence.
Кафедра урологии и хирургической андрологии Russian Federation
I. V. Lukyanov
Department of Urology and Surgical Andrology, Russian Medical Academy of Postgraduate EducationКафедра урологии и хирургической андрологии Russian Federation
D. Yu. Tuzov
Department of Urology and Surgical Andrology, Russian Medical Academy of Postgraduate EducationКафедра урологии и хирургической андрологии Russian Federation
A. N. Tyulpakov
Department of Hereditary Endocrinopathies and Laboratory of Molecular Diagnosis, Endocrinology Research Center, Russian Agency for Health Care, Moscow
Отделение наследственных эндокринопатий и лаборатория молекулярной диагностики
Russian FederationReferences
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