18F-PSMA-1007 and 18F-fluorocholine PET/CT in prostate cancer progression diagnostics. First comparative experience
https://doi.org/10.17650/1726-9776-2019-15-3-70-76
Abstract
Background. Prostate cancer progression remains as a major problem among patients after their radical treatment. During last years a broad spectrum radiopharmaceuticals had developed to reveal the cause of biochemical recurrence.
Objective: the comparison of 18F-fluorocholine and 18F-prostate-specific membrane antigen-1007 (18F-PSMA-1007) diagnostic abilities for the prostate cancer progression detection.
Materials and methods. In this study had been included 18F-fluorocholine and 18F-PSMA-1007 PET/CT (positron emission tomography combined with computed tomography) scans of 9 patients after radical treatment with increased prostate-specific antigen (PSA) level (range 0.10–9.06 ng/ml).
Results. 18F-PSMA-1007-PET/CT detected lesions in 7 (77.8 %) out of 9 patients, after radical prostatectomy and brachytherapy, in comparison with negative 18F-fluorocholine-PET/CT results in all cases.
Conclusion. In this pilot study, 18F-PSMA-1007-PET/CT has showed high potential in pathological changes detection among patients with increased PSA level (minimum 0.10 ng/ml) and demonstrated the advantages in comparison with 18F-fluorocholine-PET/CT, especially in terms of revealing local recurrence and metastatic lymph nodes, as well as, in bone lesions early detection.
About the Authors
N. A. MeshcheriakovaRussian Federation
24 Kashirskoe Shosse, Moscow 115478
M. B. Dolgushin
24 Kashirskoe Shosse, Moscow 115478
A. I. Pronin
24 Kashirskoe Shosse, Moscow 115478
V. B. Matveev
24 Kashirskoe Shosse, Moscow 115478
A. A. Odzharova
24 Kashirskoe Shosse, Moscow 115478
D. I. Nevzorov
24 Kashirskoe Shosse, Moscow 115478
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Review
For citations:
Meshcheriakova N.A., Dolgushin M.B., Pronin A.I., Matveev V.B., Odzharova A.A., Nevzorov D.I. 18F-PSMA-1007 and 18F-fluorocholine PET/CT in prostate cancer progression diagnostics. First comparative experience. Cancer Urology. 2019;15(3):70-76. (In Russ.) https://doi.org/10.17650/1726-9776-2019-15-3-70-76