Capabilities of preoperative targeted therapy in treatment of bone metastases in renal cancer
Z. A. Yurmazov,
N. A. Lushnikova,
L. V. Spirina,
E. A. Usynin,
E. M. Slonimskaya,
I. I. Anisenya,
A. V. Bogoutdinova https://doi.org/10.17650/1726-9776-2019-15-2-35-41
Abstract
The study objective is to evaluate the effectiveness of preoperative targeted therapy, spectrum and rate of adverse events, as well as quality of life in patients with bone metastases of renal cell carcinoma.
Materials and methods. The study was conducted at the Research Institute of Oncology, Tomsk Medical Research Center between 2014 and 2018. The study included 34 patients with bone metastases of renal cell carcinoma who received preoperative targeted therapy with pazopanib for 8 weeks. All patients underwent surgical treatment of both the primary tumor and bone metastases.
Results and conclusion. It was shown that preoperative targeted therapy is characterized by a high rate of clinical response and satisfactory tolerability. In some cases, preoperative targeted therapy improves the conditions for surgical treatment of metastatic bone lesions, decreases intraoperative blood loss, decreases the volume and duration of surgical intervention, which, in turn, allows to preserve bigger range of motion in the affected bone segment and improve patients’ quality of life.
About the Authors
Z. A. Yurmazov
Cancer Research Institute
Russian Federation
Competing Interests: нет конфликтов
Russian Federation
5 Kooperativny Pereulok, Tomsk 634009
Competing Interests: нет конфликтов
N. A. Lushnikova
Cancer Research Institute
Russian Federation
Competing Interests: нет конфликтов
Russian Federation
5 Kooperativny Pereulok, Tomsk 634009
Competing Interests: нет конфликтов
L. V. Spirina
Cancer Research Institute;
Siberian State Medical University, Ministry of Health of Russia
Russian Federation
Competing Interests: нет конфликтов
Russian Federation
5 Kooperativny Pereulok, Tomsk 634009,
2 Moskovskiy Trakt, Tomsk 634050
Competing Interests: нет конфликтов
E. A. Usynin
Cancer Research Institute
Russian Federation
Competing Interests: нет конфликтов
Russian Federation
5 Kooperativny Pereulok, Tomsk 634009
Competing Interests: нет конфликтов
E. M. Slonimskaya
Cancer Research Institute
Russian Federation
Competing Interests: нет конфликтов
Russian Federation
5 Kooperativny Pereulok, Tomsk 634009
Competing Interests: нет конфликтов
I. I. Anisenya
Cancer Research Institute
Russian Federation
Russian Federation
5 Kooperativny Pereulok, Tomsk 634009
A. V. Bogoutdinova
Cancer Research Institute
Russian Federation
Competing Interests: нет конфликтов
Russian Federation
5 Kooperativny Pereulok, Tomsk 634009
Competing Interests: нет конфликтов
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For citations:
Yurmazov Z.A., Lushnikova N.A., Spirina L.V., Usynin E.A., Slonimskaya E.M., Anisenya I.I., Bogoutdinova A.V. Capabilities of preoperative targeted therapy in treatment of bone metastases in renal cancer. Cancer Urology. 2019;15(2):35-41. (In Russ.) https://doi.org/10.17650/1726-9776-2019-15-2-35-41
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