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Metastatic renal cell carcinoma kidney in children 10 years old – possibility of targeted therapy

https://doi.org/10.17650/1726-9776-2017-13-4-126-132

Abstract

Renal cell carcinoma (RCC) is rare in children, its metastatic form is even rarer. At present there is no treatment protocol for children with RCC. This clinical observation presented the patient 10 year old with RCC metastases to the lungs. After radical surgery, after targeted sorafenib therapy the patient has a positive dynamics. At present his progression-free survival is 30 months.

About the Authors

A. Yu. Pavlov
Russian Scientific Center of Roentgen Radiology
Russian Federation
86 Profsoyuznaya St., Moscow 117997


Z. R. Sabirzyanova
Russian Scientific Center of Roentgen Radiology
Russian Federation
86 Profsoyuznaya St., Moscow 117997


O. G. Zheludkova
Russian Scientific Center of Roentgen Radiology
Russian Federation
86 Profsoyuznaya St., Moscow 117997


A. V. Mikhalchenko
Russian Scientific Center of Roentgen Radiology
Russian Federation
86 Profsoyuznaya St., Moscow 117997


References

1. Otgün I., Arda I.S., Haberal N. et al. Renal cell carcinoma: case report and literature review. J Pediatr Surg 2005;40(5):e13–6. DOI: 10.1016/j.jpedsurg.2005.02.013. PMID: 15937800.

2. Indolfi P., Terenziani M., Casale F. et al. Renal cell carcinoma in children: a clinicopathologic study. J Clin Oncol 2003;21(3):530–5. DOI: 10.1200/JCO.2003.02.072. PMID: 12560445.

3. Uchiyama M., Iwafuchi M., Yagi M. et al. Treatment of childhood renal cell carcinoma with lymph node metastasis: 2 cases and a review of literature. J Surg Oncol 2000;75(4):266–9. PMID: 11135269.

4. Geller J.I., Dome J.S. Local lymph node involvement does not predict poor outcome in pediatric renal cell carcinoma. Cancer 2004;101(7):1575–83. DOI: 10.1002/cncr.20548. PMID: 15378495.

5. Asanuma H., Nakai H., Takeda M. et al. Renal cell carcinoma in children: experience at a single institution in Japan. J Urol 1999;162(4):1402–5. PMID: 10492224.

6. Indolfi P., Spreafico F., Collini P. et al. Metastatic renal cell carcinoma in children and adolescents: a 30-year unsuccessful story. J Pediatr Hematol Oncol 2012;34(7):e277–81. DOI: 10.1097/MPH.0b013e318267fb12. PMID: 23007345.

7. Ismail-zade R.S., Zhavrid E.A., Potapnev M.P. Whole body hyperthermia in adjuvant therapy of children with renal cell carcinoma. Pediatr Blood Cancer 2005;44(7):679–81. DOI: 10.1002/pbc.20299. PMID: 15700247.

8. Estrada C.R., Suthar A.M., Eaton S.H. et al. Renal cell carcinoma: Children’s Hospital Boston experience. Urology 2005;66(6):1296–300. DOI: 10.1016/j.urology.2005.06.104. PMID: 16360460.

9. Motzer R.J., Bander N.H., Nanus D.M. Renal cell carcinoma. N Engl J Med 1996;335(12):865–75. DOI: 10.1056/NEJM199609193351207. PMID: 8778606.

10. Brok J., Treger T.D., Gooskens S.L. et al. Biology and treatment of renal tumours in childhood. Eur J Cancer 2016;68:179–95. DOI: 10.1016/j.ejca.2016.09.005. PMID: 27969569.

11. Hansel D.E., Rini B.I. Molecular genetics of hereditary renal cancer: new genes and diagnostic and therapeutic opportunities. Expert Rev Anticancer Ther 2008;8(6): 895–905. DOI: 10.1586/14737140.8.6.895. PMID: 18533799.

12. Linehan W.M., Srinivasan R., Schmidt L.S. The genetic basis of kidney cancer: a metabolic disease. Nat Rev Urol 2010;7(5): 277–85. DOI: 10.1038/nrurol.2010.47. PMID: 20448661.

13. Clark P.E. The role of VHL in clear-cell renal cell carcinoma and its relation to targeted therapy. Kidney Int 2009;76(9):939–45. DOI: 10.1038/ki.2009.296. PMID: 19657325.


Review

For citations:


Pavlov A.Yu., Sabirzyanova Z.R., Zheludkova O.G., Mikhalchenko A.V. Metastatic renal cell carcinoma kidney in children 10 years old – possibility of targeted therapy. Cancer Urology. 2017;13(4):126-132. (In Russ.) https://doi.org/10.17650/1726-9776-2017-13-4-126-132

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ISSN 1726-9776 (Print)
ISSN 1996-1812 (Online)
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