Melanoma of the penis and urethra: literature review and observations from clinical practice
A. K. Nosov,
S. B. Petrov,
G. I. Gafton,
S. A. Protsenko,
M. Yu. Myasnyankin,
A. V. Vorob’ev, 
E. M. Mamizhev,
I. B. Dzhalilov,
K. A. Khashirov
E. M. Mamizhev,
I. B. Dzhalilov,
K. A. Khashirov https://doi.org/10.17650/1726-9776-2017-13-2-113-120
Abstract
One of clinical and anatomical types of melanoblastoma is melanoma of the glans penis appearing on the skin or mucosa of the penis (external opening of the urethra or ureter, internal or external layer of the foreskin). It’s a rare disease, and most of specialists are unfamiliar with it, including oncologists and urologists. Thus, the conducted research has practical importance as it may improve diagnostics and treatment of patients with this oncological pathology.
About the Authors
A. K. Nosov
N.N. Petrov Reseach Institute of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
S. B. Petrov
N.N. Petrov Reseach Institute of Oncology, Ministry of Health of Russia;
A.M. Nikiforov Russian Center of Emergency and Radiation Medicine, Ministry of Russia for Civil Defense, Emergencies and Elimination of Consequences of Natural Disasters
Russian Federation
Russian Federation
G. I. Gafton
N.N. Petrov Reseach Institute of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
S. A. Protsenko
N.N. Petrov Reseach Institute of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
M. Yu. Myasnyankin
N.N. Petrov Reseach Institute of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
A. V. Vorob’ev
I.I. Mechnikov North-western State Medical University, Ministry of Health of Russia
Russian Federation
41 Kirochnaya St., Saint Petersburg 191015
Competing Interests: ФГБОУ ВО «Северо-Западный медицинский государственный университет им. И.И. Мечникова» Минздрава России
Russian Federation
41 Kirochnaya St., Saint Petersburg 191015
Competing Interests: ФГБОУ ВО «Северо-Западный медицинский государственный университет им. И.И. Мечникова» Минздрава России
E. M. Mamizhev
N.N. Petrov Reseach Institute of Oncology, Ministry of Health of Russia
Russian Federation
68 Leningradskaya St., Pesochnyy Settlement, Saint Peterburg 197758
Russian Federation
68 Leningradskaya St., Pesochnyy Settlement, Saint Peterburg 197758
I. B. Dzhalilov
N.N. Petrov Reseach Institute of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
K. A. Khashirov
N.N. Petrov Reseach Institute of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
References
1. Каприн А.Д., Старинский В.В., Петрова Г.В. Злокачественные новообразования в России в 2015 году. М.: МНИОИ им. П.А. Герцена – филиал ФГБУ «НМИРЦ» Минздрава России, 2017. 250 с. [Kaprin A.D., Starinskiy V.V., Petrova G.V. Malignant tumors in Russia in 2015. Moscow: MNIOI im. P.A. Gertsena – filial FGBU “NMIRTS” Minzdrava Rossii, 2017. 250 р. (In Russ.)].
2. World Health Organization. Skin cancers. Available at: www.who.int. (last accessed September 15, 2011).
3. Ferlay J., Shin H.R., Bray F. et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010;127(12):2893–917. DOI: 10.1002/ijc.25516. PMID: 21351269.
4. Статистика злокачественных новообразований в России и странах СНГ в 2012 г. Под ред. М.И. Давыдова, Е.М. Аксель. М.: Издательская группа РОНЦ, 2014. 226 с. [Statistics of malignant tumors in Russia and CIS countries in 2012. Eds.: М.I. Davydov, Е.М. Аksel’. Мoscow: Izdatel’skaya gruppa RONTS, 2014. 226 p. (In Russ.)].
5. Мяснянкин М.Ю., Гафтон Г.И., Анисимов В.В. и др. Акральная лентигинозная меланома: современное состояние проблемы. Вопросы онкологии 2015;61(4):563–70. [Myasnyankin M.Yu., Gafton G.I., Anisimov V.V. et al. Acral lentiginous melanoma: the current state of the problem. Voprosy onkologii = Issues of Oncology 2015;61(4):563–70. (In Russ.)].
6. El-Safadi S., Estel R., Mayser P., Muenstedt K. Primary malignant melanoma of the urethra: a systematic analysis of the current literature. Arch Gynecol Obstet 2014;289(5):935–43. DOI: 10.1007/s00404-013-3130-3. PMID: 24370958.
7. Oliva E., Quinn T.R., Amin M.B. et al. Primary malignant melanoma of the urethra: a clinicopathologic analysis of 15 cases. Am J Surg Pathol 2000;24(6):785–96. PMID: 10843280.
8. van Geel A.N., den Bakker M.A., Kirkels W. et al. Prognosis of primary mucosal penile melanoma: a series of 19 Dutch patients and 47 patients from the literature. Urology 2007;70(1):143–7. DOI: 10.1016/j.urology.2007.03.039. PMID: 17656225.
9. Seetharamu N., Ott P.A., Pavlick A.C. Mucosal melanomas: a case-based review of the literature. Oncologist 2010;15(7):772–81. DOI: 10.1634/theoncologist.2010-0067. PMID: 20571149.
10. Garbe C., Peris K., Hauschild A. et al. Diagnosis and treatment of melanoma. European consensus-based interdisciplinary guideline – Update 2016. Eur J Cancer 2016;63:201–17. DOI: 10.1016/j.ejca.2016.05.005. PMID: 27367293.
11. Stillwell T.J., Zincke H., Gaffey T.A., Woods J.E. Malignant melanoma of the penis. J Urol 1988;140(1):72–5. PMID: 3379702.
12. Papeš D., Altarac S. Melanoma of the female urethra. Med Oncol 2013;30(1):329. DOI: 10.1007/s12032-012-0329-2. PMID: 23254965.
13. Bracken R.B., Diokno A.C. Melanoma of the penis and the urethra: 2 case reports and review of the literature. J Urol 1974;111(2):198–200. PMID: 4810764.
14. Oldbring J., Mikulowski P. Malignant melanoma of the penis and male urethra. Report of nine cases and review of the literature. Cancer 1987;59(3):581–7. PMID: 3791167.
15. Levine R.L. Urethral cancer. Cancer 1980;45(7 Suppl):1965–72. PMID: 7370946.
16. Sugaya K., Yataki T., Yshikawa S., Kanoh S. A case of amelanotic malignant melanoma of the female urethra. Jap J Cein Oncol 1983;13(2):435–9. PMID: 6887560.
17. Pow-Sang J.M., Klimberg I.W., Hackett R.L., Wajsman Z. Primary malignant melanoma of the male urethra. J Urol 1988;139(6):1304–6. PMID: 3286893.
18. Robert C., Schachter J., Long G.V. et al. Pembrolizumab versus ipilimumab in advanced melanoma. N Engl J Med 2015;375(26):2521–32. DOI: 10.1056/NEJMoa1503093. PMID: 25891173.
Review
For citations:
Nosov A.K., Petrov S.B., Gafton G.I., Protsenko S.A., Myasnyankin M.Yu., Vorob’ev A.V., Mamizhev E.M., Dzhalilov I.B., Khashirov K.A. Melanoma of the penis and urethra: literature review and observations from clinical practice. Cancer Urology. 2017;13(2):113-120. (In Russ.) https://doi.org/10.17650/1726-9776-2017-13-2-113-120
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