Malignant paraganglioma of the urinary bladder. Description of clinical cases

Paraganglioma is hormonally active tumor originating from chromaffin tissue of sympathoadrenal system that secrete large amounts of catecholamines. Paraganglioma of the urinary bladder is a rare neoplasm, constituting approximately 0.06 % of all tumors of this localization. It is believed that this disease arises from embryonic remnants of chromaffin cells in the sympathetic plexus of the detrusor. Up to 10 % of these tumors have malignant origin. Diagnosis and tactics of treatment of patients with malignant paragangliomas of the bladder presents certain difficulties. The article describes 2 clinical observations of patients with this bladder pathology. 

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