Genetic predisposition markers for prostate cancer
https://doi.org/10.17650/1726-9776-2015-11-3-16-23
Abstract
Prostate cancer (PC), like most cancers, belongs to multifactorial diseases arising from an interaction between environmental factors and
an individual’s genotype. The paper reviews the literature on the genetic predisposition to PC, which is determined by both rare gene mutations with high penetrance and inherited polymorphic genetic variants with low penetrance. The paper considers the clinical aspects of genetic predisposition to PC, among other factors, the need for male screening for both types of genetic abnormalities to assess the risk of this cancer.
About the Authors
M. D. Kanaeva
Russian Research Center for Radiology and Surgical Technologies, Ministry of Health of Russia; 70, Leningradskaya St., Pesochnyi Settlement, Saint Petersburg 197758, Russia
Russian Federation
Russian Federation
I. E. Orobtsova
Russian Research Center for Radiology and Surgical Technologies, Ministry of Health of Russia; 70, Leningradskaya St., Pesochnyi Settlement, Saint Petersburg 197758, Russia
Russian Federation
Russian Federation
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Review
For citations:
Kanaeva M.D., Orobtsova I.E. Genetic predisposition markers for prostate cancer. Cancer Urology. 2015;11(3):16-23. (In Russ.) https://doi.org/10.17650/1726-9776-2015-11-3-16-23
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