Testicular germ cell tumors: Molecular genetic and clinicomorphological aspects
https://doi.org/10.17650/1726-9776-2015-1-12-19
Abstract
Testicular tumors are the most common form of solid cancer in young men. According to the 2004 WHO classification, testicular germ cell tumors (TGCT) may present with different histological types. Embryonic cells of varying grade may be a source of TGCT and the occurrence of this type of tumors is directly related to the formation of a pool of male sex cells and gametogenesis. The paper gives information on mo- lecular stages for the process of formation of male sex cells in health, as well as ways of their impairments leading to TGCT. An investigation of the profiles of gene expression and the spectrum of molecular damages revealed genes responsible for a predisposition to the sporadic and hereditary forms of TGCT.
The paper presents the current molecular genetic and clinicomorphological characteristics of TGCT.
About the Authors
M. V. Nemtsova
Russian Academy of Postgraduate Education, Ministry of Health of Russia; 2/1, Barrikadnaya St., Moscow 125 995, Russia
Russian Federation
Russian Federation
Yu. Yu. Andreeva
Russian Academy of Postgraduate Education, Ministry of Health of Russia; 2/1, Barrikadnaya St., Moscow 125 995, Russia
Russian Federation
Russian Federation
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Review
For citations:
Nemtsova M.V., Andreeva Yu.Yu. Testicular germ cell tumors: Molecular genetic and clinicomorphological aspects. Cancer Urology. 2015;11(1):12-19. (In Russ.) https://doi.org/10.17650/1726-9776-2015-1-12-19
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