MOLECULAR MARKERS FOR METASTATIC PROSTATE ADENOCARCINOMA
https://doi.org/10.17650/1726-9776-2012-8-4-48-52
Abstract
The search of molecular markers of metastasing and prognosis in prostate cancer remains an urgent task. In this study, we investigated the relationship of gene expression heparanase-1 (HPSE1) and D-glucuronil C5-epimerase (GLCE) with early disease relapse and metastasis of a 2,5−3 years after diagnosis. It was shown that the ratio of the expression levels of genes HPSE1/GLCE > 1 may serve as a prognostic relapse marker and trends of the tumour to metastasis. The data obtained suggest to use this option as a molecular marker for the diagnostics of metastatic process and the disease prognosis.
About the Authors
I. S. Kunin
Novosibirsk state medical university
Russian Federation
Russian Federation
M. M. Boboev
Novosibirsk regional clinics
Russian Federation
Russian Federation
O. S. Kutsenko
Institute of molecular biology and biophysics, Siberian Division of RAMS, Novosibirsk
Russian Federation
Russian Federation
L. A. Mostovich
Institute of molecular biology and biophysics, Siberian Division of RAMS, Novosibirsk
Russian Federation
Russian Federation
S. V. Aidagulova
Novosibirsk state medical university
Russian Federation
Russian Federation
E. V. Grigorieva
Institute of molecular biology and biophysics, Siberian Division of RAMS, Novosibirsk
Russian Federation
Russian Federation
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Review
For citations:
Kunin I.S., Boboev M.M., Kutsenko O.S., Mostovich L.A., Aidagulova S.V., Grigorieva E.V. MOLECULAR MARKERS FOR METASTATIC PROSTATE ADENOCARCINOMA. Cancer Urology. 2012;8(4):48-52. (In Russ.) https://doi.org/10.17650/1726-9776-2012-8-4-48-52
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