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PROGNOSTIC FACTORS IN PROSTATE CANCER
- Authors: Gorban N.A.1, Karyakin A.O.1
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Affiliations:
- Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk
- Issue: Vol 6, No 4 (2010)
- Pages: 47-53
- Section: PROSTATE CANCER
- Published: 30.12.2010
- URL: https://oncourology.abvpress.ru/oncur/article/view/355
- DOI: https://doi.org/10.17650/1726-9776-2010-6-4-47-53
- ID: 355
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Abstract
Prostate cancer is most common and its heterogenicity is presently apparent. There is a continuous search for the factors allowing the prediction of the poor course and biological difference of tumors. The College of American Pathologists classifies the currently known prognostic factors into 3 categories: 1) the factors whose prognostic importance and successful use have been proven in practice; 2) those that have been widely studied biologically and clinically, but the significance of which needs to be proven in extensive statistical studies; 3) all other factors that have been inadequately studied to demonstrate their prognostic value. Category 1 prognostic factors, such as prostate-specific antigen levels, TNM stage, Gleason grading, and the status of surgical margins, enjoy wide application. Category 2 factors are not used IN clinical practice so extensively. The value of some Category 3 factors (the biomarkers p53, Ki-67, Bcl-2, receptors of androgens) is indubitably and they claim to be widely applied in clinical practice with time. The clinical significance of molecular biological markers calls for further investigation.
About the authors
N. A. Gorban
Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk
Author for correspondence.
Email: perovanina@mail.ru
Russian Federation
A. O. Karyakin
Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk
Email: perovanina@mail.ru
Russian Federation
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