ROLE OF THE MORPHOMETRIC PARAMETERS OF INTRATUMORAL MICROVESSELS AND THE PROLIFERATIVE ACTIVITY OF TUMOR CELLS IN RENAL CELL CARCINOMA

Tumor cell proliferation and angiogenesis are essential factors for tumor growth, progression, and metastasis.

Objective: to assess the relationship between the values of proliferative activity and the morphometric parameters of intratumoral microvessels in metastatic and localized carcinomas of the kidney.

Materials and methods. Surgical specimens taken from 54 patients (32 men and 22 women) aged 26 to 69 years (mean age 55 ± 1.5 years) with the verified diagnosis of clear-cell renal cell carcinoma (RCC) were studied.

Conclusion. Proliferative activity and angioarchitectonics are an important biological characteristic of a tumor of unequal clinical value in RCC. Metastatic carcinoma has a higher proliferative activity and a low tumor vascularization than those of localized carcinoma.

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