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Онкоурология

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МОЛЕКУЛЯРНЫЕ МАРКЕРЫ ПРОГНОЗА ПРИ РАКЕ МОЧЕВОГО ПУЗЫРЯ

https://doi.org/10.17650/1726-9776-2012-8-2-32-36

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Аннотация

Рак мочевого пузыря (РМП) остается актуальной проблемой онкоурологии. Несмотря на то, что факторы риска РМП изучены и описаны в литературе, выявляются новые молекулярно-генетические механизмы, предрасполагающие к развитию заболевания. В патогенез РМП вовлечено множество клеточных процессов. Менее агрессивные, неинвазивные, медленно прогрессирующие формы РМП характеризуются активацией системы Ras-mitogen-activated protein kinase (Ras-MAPK). Более агрессивные опухоли с низкой раковоспецифической выживаемостью, характеризуются изменениями в генах ретинобластомы и p53. Предпринимаются попытки разработать прогностические тесты, предсказывающие развитие опухоли, выбор тактики лечения. В перспективе в лечении пациентов РМП будут использоваться молекулярно-генетические маркеры, позволяющие достоверно предсказать поведение опухоли у пациента и выбрать индивидуальную тактику лечения.

Об авторах

В. Н. Павлов
Клиника Башкирского ГМУ, Уфа ГБОУ ВПО Башкирский ГМУ Минздравсоцразвития России, Уфа
Россия


А. А. Измайлов
Клиника Башкирского ГМУ, Уфа
Россия


Л. З. Ахмадишина
ФГБУН Институт биохимии и генетики Уфимского НЦ РАН
Россия


Т. В. Викторова
ГБОУ ВПО Башкирский ГМУ Минздравсоцразвития России, Уфа ФГБУН Институт биохимии и генетики Уфимского НЦ РАН
Россия


С. М. Измайлова
ГБОУ ВПО Башкирский ГМУ Минздравсоцразвития России, Уфа
Россия


М. Ф. Урманцев
Клиника Башкирского ГМУ, Уфа
Россия


А. В. Алексеев
Клиника Башкирского ГМУ, Уфа
Россия


А. Р. Загитов
Клиника Башкирского ГМУ, Уфа
Россия


Л. М. Кутлияров
Клиника Башкирского ГМУ, Уфа
Россия


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Для цитирования:


Павлов В.Н., Измайлов А.А., Ахмадишина Л.З., Викторова Т.В., Измайлова С.М., Урманцев М.Ф., Алексеев А.В., Загитов А.Р., Кутлияров Л.М. МОЛЕКУЛЯРНЫЕ МАРКЕРЫ ПРОГНОЗА ПРИ РАКЕ МОЧЕВОГО ПУЗЫРЯ. Онкоурология. 2012;8(2):32-36. https://doi.org/10.17650/1726-9776-2012-8-2-32-36

For citation:


Pavlov V.N., Izmailov A.A., Akhmadishina L.Z., Victorova T.V., Izmailova S.M., Urmantsev M.F., Alekseev A.V., Zagitov A.R., Kutliyarov L.M. MOLECULAR PROGNOSTIC MARKERS OF URINE BLADDER CANCER. Cancer Urology. 2012;8(2):32-36. (In Russ.) https://doi.org/10.17650/1726-9776-2012-8-2-32-36

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ISSN 1726-9776 (Print)
ISSN 1996-1812 (Online)