Email this article MOLECULAR PROGNOSTIC MARKERS OF URINE BLADDER CANCER
- Authors: Pavlov V.N.1, Izmailov A.A.2, Akhmadishina L.Z.3, Victorova T.V.4, Izmailova S.M.5, Urmantsev M.F.2, Alekseev A.V.2, Zagitov A.R.2, Kutliyarov L.M.2
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Affiliations:
- Clinic of Bashkir State Medical University, Ufa Bashkir State Medical University, Ufa
- Clinic of Bashkir State Medical University, Ufa
- Institute of Biochemistry and Genetics, Ufa
- Bashkir State Medical University, Ufa Institute of Biochemistry and Genetics, Ufa
- Bashkir State Medical University, Ufa
- Issue: Vol 8, No 2 (2012)
- Pages: 32-36
- Section: DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. URINARY BLADDER CANCER
- Published: 30.06.2012
- URL: https://oncourology.abvpress.ru/oncur/article/view/314
- DOI: https://doi.org/10.17650/1726-9776-2012-8-2-32-36
- ID: 314
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Abstract
Bladder cancer (BC) remains a current problem in oncourology. Despite that bladder cancer risk factors have been studied and described in the literature, new molecular and genetic mechanisms have been identified that predisposes to the disease development. There are numerous cellular processes involve in BC pathogenesis. The less-aggressive, non-invasive slow progressing bladder cancer types are defined by Ras-MAPK system activation. Tumors that are more aggressive and have low cancer-specific survival rate are characterized by changes in retinoblastoma genes and p53. Attempts are made to develop prognostic tests to predict tumor behavior, targeted treatment. perspectively, BC patients will be treated using molecular genetic markers allowing the accurate prediction of the patient’s tumor behavior and fitting the treatment tactics on the individual basis.
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About the authors
V. N. Pavlov
Clinic of Bashkir State Medical University, UfaBashkir State Medical University, Ufa
Email: Izmailov75@mail.ru
Russian Federation
A. A. Izmailov
Clinic of Bashkir State Medical University, Ufa
Author for correspondence.
Email: Izmailov75@mail.ru
Russian Federation
L. Z. Akhmadishina
Institute of Biochemistry and Genetics, Ufa
Email: Izmailov75@mail.ru
Russian Federation
T. V. Victorova
Bashkir State Medical University, UfaInstitute of Biochemistry and Genetics, Ufa
Email: Izmailov75@mail.ru
Russian Federation
S. M. Izmailova
Bashkir State Medical University, Ufa
Email: Izmailov75@mail.ru
Russian Federation
M. F. Urmantsev
Clinic of Bashkir State Medical University, Ufa
Email: Izmailov75@mail.ru
Russian Federation
A. V. Alekseev
Clinic of Bashkir State Medical University, Ufa
Email: Izmailov75@mail.ru
Russian Federation
A. R. Zagitov
Clinic of Bashkir State Medical University, Ufa
Email: Izmailov75@mail.ru
Russian Federation
L. M. Kutliyarov
Clinic of Bashkir State Medical University, Ufa
Email: Izmailov75@mail.ru
Russian Federation
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