Preview

Cancer Urology

Advanced search

REPEATED TRANSRECTAL PROSTATE BIOPSY IN PATIENTS WITH ATYPICAL SMALL ACINA

https://doi.org/10.17650/1726-9776-2009-5-4-50-53

Abstract

Objective: to define the optimal time and technique of repeated transrectal prostate biopsy (RTPB) in patients with atypical small acinar proliferation (ASAP).

Subjects and methods: RTPB was performed in 210 patients with first diagnosed ASAP. The study was conducted on an average 8 (range 1 to 12) months after the first biopsy and involved 12, 14, 16, and 18 biopsy cores.  

Results: According to the results of repeated biopsy, prostate adenocarcinoma was verified in 64.8% (136/210) of cases. The highest detection rate was found with biopsy schemes including 16 and 18 cores 1 and 3 months after the first biopsy (p < 0.05).  

Conclusions: ASAP is a precursor of prostate cancer and its presence in the morphological specimen during the first biopsy requires RTBT in the early periods irrespective of PSA levels.

 

About the Authors

M. A. Kurdzhiev
Department of Urology, Moscow State University of Medicine and Dentistry
Russian Federation


A. V. Govorov
Department of Urology, Moscow State University of Medicine and Dentistry
Russian Federation


M. V. Kovylina
Department of Urology, Moscow State University of Medicine and Dentistry
Russian Federation


D. Yu. Pushkar
Department of Urology, Moscow State University of Medicine and Dentistry
Russian Federation


References

1. Iczkowski K.A., MacLennan D.G., Bostwick D.G. Atypical small proliferation suspicious for malignancy in prostate needle biopsy: clinical significance in 33 cases. Am J Surg Pathol 1997;21:1489—95.

2. Humphery P.A. Prostate pathology. Chicago, 2003.

3. Ковылина М.В. Клинико- морфологическая характеристика предраковых заболеваний и рака предстательной железы. Автореф. дис. … канд. мед. наук. М., 2006.

4. Iczkowski K.A., MacLennan D.G., Bostwick D.G. Atypical small proliferation suspicious for malignancy in prostate needle biopsy: clinical significance in 33 cases. Am J Surg Pathol 1997;21:1489—95.

5. Renshaw A.A., Cartagena N., Granter S.R. et al. Agreement and error rates using blinded review to evaluate surgical pathology of biopsy material. Am J Clin Pathol 2003;119:797—800.

6. Park S., Shinohara K., Grossfeld G.D., Carroll P.R. Prosyate cancer detection in men with prior high grade prostatic intraepithelial neoplasia or atypical prostate biopsy. J Urol 2001;165(5): 1409—14.

7. Iczkowski K.A., Chen H.M., Yang X.J. et al. Prostate cancer diagnosed after initial biopsy with atypical small proliferation suspicious for malignancy is similar to cancer found on initial biopsy. Urology 2002;60:851—4.

8. Brausi M., Castagnetti G., Dotti A. et al. Immediate radical prostatectomy in patients with atypical small acinar proliferation. Over treatment? J Urol 2004; 172(3):906—9.

9. Moore C.K., Karikehallis S., Nazeer T. et al. Prognostic significance of high grade prostatic intraepithelial neoplasia and atypical small acinar proliferation in the con- temporary era. J Urol 2005;173(1):70—2.

10. Girasole C.R., Cookson M.S., Putzi M.J. et al. Significance of atypical and suspicious small acinar proliferations, and high grade prostatic intraepithelial neoplasia on prostate biopsy: implications for cancer detection and biopsy strategy. J Urol 2006;175(3):929—33.


Review

For citations:


Kurdzhiev M.A., Govorov A.V., Kovylina M.V., Pushkar D.Yu. REPEATED TRANSRECTAL PROSTATE BIOPSY IN PATIENTS WITH ATYPICAL SMALL ACINA. Cancer Urology. 2009;5(4):50-53. (In Russ.) https://doi.org/10.17650/1726-9776-2009-5-4-50-53

Views: 2129


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1726-9776 (Print)
ISSN 1996-1812 (Online)
X