THE PROGNOSTIC AND DIAGNOSTIC VALUE OF REPEATED TRANSRECTAL PROSTATE SATURATION BIOPSY
https://doi.org/10.17650/1726-9776-2009-5-2-61-64
Abstract
Objective: to determine the rate of prostate cancer (PC) development after repeated transrectal saturation prostate biopsy (RTRSPB), to study the characteristics of diagnosed tumors, and to estimate their clinical significance from the data of radical retropubic prostatectomy (RRP).
Materials and methods. The results of RTRSPB were analyzed in 226 patients with a later evaluation of a tumor from the results of RRP. All the patients underwent at least 2 prostate biopsies (mean 2.4). The average number of biopsy cores was 26.7 (range 24—30). The average value of total prostate-specific antigen before saturation biopsy was 7.5 (range 7.5 to 28.6) ng/ml. The mean age of patients was 62 years (range 53 to 70).
Results. PC was diagnosed in 14.6% of cases (33/226). An isolated lesion of the prostatic transition zone was in 12.1% of cases. If this zone had been excluded from the biopsy scheme, the detection rate of PC during saturation biopsy should be reduced by 13.8%. Better PC detectability during repeated saturation biopsy generally occurred due to the localized forms of the disease (93.3%). The agreement of Gleason tumor grading in the biopsy and prostatectomy specimens was noted in 66.7% of cases.
Conclusion. Saturation biopsy allows prediction of a pathological stage of PC, Gleason grade of a tumor and its site localization with a greater probability. Most tumors detectable by saturation biopsy were clinically significant, which makes it possible to recommend RTRSPB to some cohort of high PC-risk patients
About the Authors
M. A. Kurdzhiev
Department of Urology, Moscow State University of Medicine and Dentistry
Russian Federation
Russian Federation
A. V. Govorov
Department of Urology, Moscow State University of Medicine and Dentistry
Russian Federation
Russian Federation
M. V. Kovylina
Department of Urology, Moscow State University of Medicine and Dentistry
Russian Federation
Russian Federation
D. Yu. Pushkar
Department of Urology, Moscow State University of Medicine and Dentistry
Russian Federation
Russian Federation
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Review
For citations:
Kurdzhiev M.A., Govorov A.V., Kovylina M.V., Pushkar D.Yu. THE PROGNOSTIC AND DIAGNOSTIC VALUE OF REPEATED TRANSRECTAL PROSTATE SATURATION BIOPSY. Cancer Urology. 2009;5(2):61-64. (In Russ.) https://doi.org/10.17650/1726-9776-2009-5-2-61-64
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