Solitary fibrous tumor of the prostate: clinical case and literature review
https://doi.org/10.17650/1726-9776-2024-20-2-116-121
Abstract
Solitary fibrous tumor of the prostate is an extremely rare neoplasm of mesenchymal nature. To date, about 40 cases of this pathology have been described in international literature. Solitary fibrous tumors are asymptomatic for a long time and are usually an incidental radiological examination. To differentiate a solitary fibrous tumor from other mesenchymal neoplasms, it is necessary to conduct an immunohistochemical study to determine STAT6 expression. The main and most effective method of treatment is surgery. In this article we present a unique clinical case of a patient with synchronous tumors: malignant solitary fibrous tumor of the prostate (risk of metastasis (WHO 2020) intermediate); prostate cancer stage II (pT2N0M0R0, Gleason 6 (3 + 3)).
About the Authors
K. A. Firsov
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Konstantin Andreevich Firsov
24 Kashirskoe Shosse, Moscow 115522
F. I. Salimzyanov
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115522
O. A. Khalmurzaev
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115522
A. I. Koltunova
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115522
O. T. Khvan
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115522
V. B. Matveev
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115522
References
1. Marcal L.P., Surabhi V.R., Ramani N.S. et al. Mesenchymal neoplasms of the prostate and seminal vesicles: spectrum of disease with radiologic-pathologic correlation. Radiographics 2022;2(42):417–32. DOI: 10.1148/rg.210084
2. Peng Y., Jiang Y., Ding S. et al. Solitary fibrous tumors in prostate: a case report with review of the literature. Aging Male 2022;1(25):219–27. DOI: 10.1080/13685538.2022.2110232
3. Wagner E. Das tuberkelahnliche lymphadenom (der cytogene oder reticulirte tuberkel). Leipzig Arch Heilk 1870;11:497. Available at: https://archive.org/details/b21705781
4. Klemperer P., Coleman B.R. Primary neoplasm of the pleura: a report of five cases. Arch Pathol 1931;11:385–412.
5. Minin K.V., Kononec P.V., Polotskiy B.E., Mochal’nikova V.V. Solitary fibrous tumor pleura. Review of literature and treatment experience of 30 patients. Onkologiya. Zhurnal im. P.A. Gertsena = P.A. Herzen Journal of Oncology 2020;9(2):22–9. (In Russ.). DOI: 10.17116/onkolog2020902122
6. Ryabov A.B., Pikin O.V., Abu-Khaidar O.B. Solitary fibrous malignant tumor of the pleura with associated hypoglycemia: a case report. Sibirskiy onkologicheskiy zhurnal = Siberian Journal of Oncology 2020;19(2):147–52. (In Russ.) DOI: 10.21294/1814-4861-2020-19-2-147-152
7. Demicco E.G., Fritchie K.J., Han A. Solitary fibrous tumour. In: The WHO Classification of Tumours Editorial Board. WHO Classification of Tumours. Soft Tissue and Bone Tumours. 5th edn. World Health Organization, 2020. Pp. 104–108.
8. Demicco E.G., Park M.S., Araujo D.M. et al. Solitary fibrous tumor: a clinicopathological study of 110 cases and proposed risk assessment model. Mod Pathol 2012;25(9):1298–306. DOI: 10.1038/modpathol.2012.83
9. Olson N.J., Linos K. Dedifferentiated solitary fibrous tumor: a concise review. Arch Pathol Lab Med 2018;6(142):761–6. DOI: 10.5858/arpa.2016-0570-RS
10. Ronchi A., Mantia E.L., Gigantino V. et al. A rare case of malignant solitary fibrous tumor in prostate with review of the literature. Diagn Pathol 2017;1(12):50. DOI: 10.1186/s13000-017-0640-5
11. Machado I., Nieto-Morales G., Cruz J. et al. Controversial issues in soft tissue solitary fibrous tumors: a pathological and molecular review. Pathol Int 2020;70(3):129–39.
12. Robinson L.A. Solitary fibrous tumor of the pleura. Cancer Control 2006;13(4):264–9. DOI: 10.1111/pin.12894
13. Stacchiotti S., Negri T., Palassini E. et al. Sunitinib malate and figitumumab in solitary fibrous tumor: patterns and molecular bases of tumor response. Mol Cancer Ther 2010;9(5):1286–97. DOI: 10.1158/1535-7163.MCT-09-1205
14. Quek R., Wang Q., Morgan J.A. et al. Combination mTOR and IGF-1R inhibition: phase I trial of everolimus and figitumumab in patients with advanced sarcomas and other solid tumors. Clin Cancer Res 2011;17(4):871–9. DOI: 10.1158/1078-0432.CCR-10-2621
15. Schwartz G.K., Tap W.D., Qin L.X. et al. Cixutumumab and temsirolimus for patients with bone and soft-tissue sarcoma: a multicenter, open-label, phase 2 trial. Lancet Oncol 2013;14(4):371–82. DOI:10.1016/S1470-2045(13)70049-4
16. Stacchiotti S., Baldi G.G., Frezza A.M. Regorafenib in advanced solitary fibrous tumour: results from an exploratory phase II clinical study. Eur J Cancer 2023;195:13391. DOI: 10.1016/j.ejca.2023.113391
Review
For citations:
Firsov K.A., Salimzyanov F.I., Khalmurzaev O.A., Koltunova A.I., Khvan O.T., Matveev V.B. Solitary fibrous tumor of the prostate: clinical case and literature review. Cancer Urology. 2024;20(2):116-121. (In Russ.) https://doi.org/10.17650/1726-9776-2024-20-2-116-121
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