Prognostic factors affecting survival of patients with penile cancer receiving treatment in wide clinical practice
https://doi.org/10.17650/1726-9776-2024-20-3-117-129
Abstract
Aim. To evaluate the effect of prognostic factors on survival rates of patients with penile cancer and to identify groups of patients with favorable and unfavorable prognoses.
Materials and methods. Retrospective analysis of data of 197 patients with penile cancer who were treated at the Moscow City Oncological Hospital No. 62 and Clinical Oncological Dispensary (Omsk) between 1997 and 2023 was performed.
Results. Statistically significant prognostic factors affecting survival rates of patients with penile cancer according to univariate analysis (log-rank test with p <0.05) and multivariate Cox regression analysis are: clinical stage (I–IV), T stage (T1–T3), resection margin (R0–R1), N grade (N0–N3), lymphovascular invasion, extranodal extension of metastasis to the inguinal lymph nodes, necrosis of the primary tumor, iliac lymph node involvement. Factors without significant effect on survival are: morphological structure of the tumor (p = 0.73), radiation therapy of the primary tumor (p = 0.38), chemotherapy (p = 0.46).
Conclusion. Analysis of clinical and pathomorphological factors allowed to identify an unfavorable prognosis group in patients with penile cancer for a personalized approach to improve survival rates.
About the Authors
V. I. Shirokorad
Moscow City Oncological Hospital No. 62, Moscow Healthcare Department
Russian Federation
Russian Federation
27 Istra, Moscow Region 143515
S. V. Kostritskiy
Moscow City Oncological Hospital No. 62, Moscow Healthcare Department
Russian Federation
Russian Federation
Stanislav V. Kostritskiy
27 Istra, Moscow Region 143515
D. V. Semenov
Saint Petersburg State University;
City Clinical Oncological Dispensary
Russian Federation
Russian Federation
7–9 Universitetskaya Naberezhnaya, Saint Petersburg 199034,
56 Prospekt Veteranov, Saint Petersburg 198255
D. D. Yakubova
Moscow City Oncological Hospital No. 62, Moscow Healthcare Department
Russian Federation
Russian Federation
27 Istra, Moscow Region 143515
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22.
Review
For citations:
Shirokorad V.I., Kostritskiy S.V., Semenov D.V., Yakubova D.D. Prognostic factors affecting survival of patients with penile cancer receiving treatment in wide clinical practice. Cancer Urology. 2024;20(3):117-129. (In Russ.) https://doi.org/10.17650/1726-9776-2024-20-3-117-129
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