Progressive prostate cancer with metastasis in the urethra: clinical case
A. A. Kеln,
D. G. Alifov,
A. V. Ratobolskikh,
M. A. Zasorina,
L. V. Volynkina,
A. V. Kupchin,
V. G. Novoselov,
A. V. Vayradyan,
M. S. Shvedskiy https://doi.org/10.17650/1726-9776-2022-18-4-136-140
Abstract
Prostate cancer metastases are a major cause of death among men. Almost all men who died from prostate cancer previously had metastases to the bones or other sites, including the lymph nodes, lung, and liver. Urethral metastases are one of the rarest locations of prostate cancer metastases. In this clinical case, we present a case of a man who had a recurrence of prostatic adenocarcinoma 36 months after radical prostatectomy; diagnosis and treatment of the patient are described.
Supporting agencies: The work was performed without external funding.
About the Authors
A. A. Kеln
Tyumen State Medical University, Ministry of Health of Russia;
Multispecialty Clinical Medical Center “Medical City”;
Regional Urological Center, “Neftyannik”
Russian Federation
Russian Federation
Artem Aleksandrovich Kеln
54 Odesskaya St., Tyumen 625023;
32 Barnaul’skaya St., Tyumen 625000;
8/1 Yuriya Semovskykh St., Tyumen 625000
D. G. Alifov
Tyumen State Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
54 Odesskaya St., Tyumen 625023
A. V. Ratobolskikh
Tyumen State Medical University, Ministry of Health of Russia;
Multispecialty Clinical Medical Center “Medical City”
Russian Federation
Russian Federation
54 Odesskaya St., Tyumen 625023;
32 Barnaul’skaya St., Tyumen 625000;
M. A. Zasorina
Tyumen State Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
54 Odesskaya St., Tyumen 625023
L. V. Volynkina
Multispecialty Clinical Medical Center “Medical City”
Russian Federation
Russian Federation
32 Barnaul’skaya St., Tyumen 625000
A. V. Kupchin
Multispecialty Clinical Medical Center “Medical City”;
Regional Urological Center, “Neftyannik”
Russian Federation
Russian Federation
32 Barnaul’skaya St., Tyumen 625000;
8/1 Yuriya Semovskykh St., Tyumen 625000
V. G. Novoselov
Regional Urological Center, “Neftyannik”
Russian Federation
Russian Federation
8/1 Yuriya Semovskykh St., Tyumen 625000
A. V. Vayradyan
Multispecialty Clinical Medical Center “Medical City”;
Regional Urological Center, “Neftyannik”
Russian Federation
Russian Federation
32 Barnaul’skaya St., Tyumen 625000;
8/1 Yuriya Semovskykh St., Tyumen 625000
M. S. Shvedskiy
Tyumen State Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
54 Odesskaya St., Tyumen 625023
References
1. Rawla P. Epidemiology of prostate cancer. World J Oncol 2019;10(2):63–89. DOI: 10.14740/wjon1191
2. Litwin M.S., Tan H.J. The diagnosis and treatment of prostate cancer: a review. JAMA 2017;317(24):2532–42. DOI: 10.1001/jama.2017.7248
3. Keln A.A., Alifov D.G., Kupchin A.V. Improvement of screening programs for early detection of prostate cancer. Akademicheskiy zhurnal Zapadnoy Sibiri = Academic Journal of West Siberia 2019;15(5 (82)):42–3. (In Russ.).
4. Holm H.V., Dahl A.A., Klepp O.H., Fosså S.D. Modern treatment of metastatic prostate cancer. Tidsskr Nor Laegeforen 2017;137(11):803–5. DOI: 10.4045/tidsskr.16.0265
5. Eng T.Y., Chen T.W., Patel A.J. et al. Treatment and outcomes of primary urethra cancer. Am J Clin Oncol 2018;41(9):905–8. DOI: 10.1097/COC.0000000000000391
6. Aydin F. Endometrioid adenocarcinoma of prostatic urethra presenting with anterior urethral implantation. Urology 1993;41(1):91–5. DOI: 10.1016/0090-4295(93)90255-9
7. Taylor G.B., McNeal J.E., Cohen R.J. Intraductal carcinoma of the prostate metastatic to the penile urethra: a rare demonstration of two morphologic patterns of tumor growth. Pathology 1998;30(2):218–21. DOI: 10.1080/00313029800169306
8. Ohyama C., Takyu S., Yoshikawa K. et al. Adenocarcinoma arising from the prostatic duct mimicking transitional cell carcinoma. Int J Urol 2001;8(7):408–11. DOI: 10.1046/j.1442-2042.2001.00323.x
9. Green J.M., Tang W.W., Jensen B.W., Orihuela E. Isolated recurrence of ductal prostate cancer to anterior urethra. Urology 2006;68(2):428.e13–5. DOI: 10.1016/j.urology.2006.03.024
10. Dong X., Wang L., Taniguchi K. et al. Mutations in CHEK2 associated with prostate cancer risk. Am J Hum Genet 2003;72(2):270–80. DOI: 10.1086/346094
11. Stolarova L., Kleiblova P., Janatova M. et al. CHEK2 germline variants in cancer predisposition: stalemate rather than checkmate. Cells 2020;9(12):2675. DOI: 10.3390/cells9122675
12. Isaacsson Velho P., Silberstein J.L., Markowski M.C. et al. Intraductal/ductal histology and lymphovascular invasion are associated with germline DNA-repair gene mutations in prostate cancer. Prostate 2018;78(5):401–7. DOI: 10.1002/pros.23484
13. Giri V.N., Hegarty S.E., Hyatt C. et al. Germline genetic testing for inherited prostate cancer in practice: implications for genetic testing, precision therapy, and cascade testing. Prostate 2019;79(4):333–9. DOI: 10.1002/pros.23739
14. Wu Y., Yu H., Zheng S.L. et al. A comprehensive evaluation of CHEK2 germline mutations in men with prostate cancer. Prostate 2018;78(8):607–15. DOI: 10.1002/pros.23505
15. Yadav S., Hu C., Hart S.N. et al. Evaluation of germline genetic testing criteria in a hospital-based series of women with breast cancer. J Clin Oncol 2020;38(13):1409–18. DOI: 10.1200/JCO.19.02190
Review
For citations:
Kеln A.A., Alifov D.G., Ratobolskikh A.V., Zasorina M.A., Volynkina L.V., Kupchin A.V., Novoselov V.G., Vayradyan A.V., Shvedskiy M.S. Progressive prostate cancer with metastasis in the urethra: clinical case. Cancer Urology. 2022;18(4):136-140. (In Russ.) https://doi.org/10.17650/1726-9776-2022-18-4-136-140
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