Survival in bladder cancer in Samara region taking into account the stage of the disease and location

Background. Survival rates play an important role in improving the organization of oncological care and individualization of treatment methods. The presence of databases of patients with bladder cancer in the Samara region makes it possible to study survival at the population level, taking into account the place of residence, gender, stage of the disease, the histological structure of the tumor, and allows you to participate in the further formation of the federal cancer registry as part of the digitalization of healthcare.

Aim. To study of survival rates for bladder cancer in the Samara region for the period 2010–2012 with the calculation of 5-year survival for 2017.

Materials and methods. The study included data on 1138 patients with newly diagnosed bladder cancer. Calculation and analysis of relapse-free, overall and tumor-specific survival of 1059 patients with bladder cancer was carried out, taking into account the place of residence and gender differences. Of these, 846 (79.9 %) people are urban residents, 213 (20.1 %) are from rural areas (4:1). A comparative analysis of the survival of patients with bladder cancer for 2000–2002 and 2010–2012 was performed. The Kaplan–Meier method was used to calculate survival rates.

Results. An analysis of the survival of patients with bladder cancer found lower overall survival compared to tumor-specific survival, which indicates the presence of intercurrent causes of death. In the population of the region as a whole, 1-year relapse-free, overall and tumor-specific survival in this disease was 75.9, 77.9 and 81.1 %, 5-year – 55.7, 53.8 and 66.6 %, respectively. An assessment of the dynamics of the probability of living each year showed that the majority of patients (18.9 %) die during the first year of observation, in subsequent years the probability of survival is much higher. Life expectancy in urban areas is longer than in rural areas. Comparison of gender differences in survival revealed lower survival rates in the male population. Indicators of 1-year and 5-year tumor-specific survival of patients for 2010–2012 increased by 5.7 % and 13.6 %, respectively, as compared to 2000–2002.

Conclusion. Comparative analysis of 1-year and 5-year survival of patients with bladder cancer in the Samara region for 2010–2012 determined the low survival rates of rural men compared to urban ones. Higher survival rate for this disease for 2010–2012 compared to 2000–2002 may indicate an increase in the availability of specialist care to the population and careful monitoring of patients in the last decade of the study.

1. Malignant tumors in Russia in 2019 (morbidity and mortality). Eds.: А.D. Kaprin, V.V. Starinskiy, A.O. Shachzadova. Moscow: MNIOI im. P.A. Gertsena – filial FGBU “NMITS radiologii” Minzdrava Rossii, 2020. 252 p. (In Russ.).

2. Merabishvili V.M. Cancer statistics (traditional methods and new information technologies). Guideline for physicians. Part II. Saint Petersburg: Kosta, 2015. 248 p. (In Russ.).

3. Survival of Cancer Patients in Europe The EUROCARE. 5 Study: Section 1: Survival Analysis 2000–2007. Available at: https://w3.iss.it/site/EU5Results/forms/SA0007.aspx.

4. SEER cancer Statistics Review 1975–2016. Available at: https://seer.cancer.gov/archive/csr/1975_2017/results_merged/sect_27_urinary_bladder.pdf.

5. Cancer Incidence in Five Continents. Eds.: D. Parkin, S. Whelan, J. Ferlay, L. Teppo, D. Thomas. Vol. VIII. No. 155. Lyon: IARC Scientific Publications, 2002. 781 p.

6. Cancer Incidence in Five Continents. Eds.: M.P. Curado, B. Edwards, H.R. Shin et al. Vol. IX. No. 160. Lyon: IARC Scientific Publications, 2007.

7. Mackay J., Jemal A., Lee N.C., Parkin M. The cancer Atlas, 2006. 128 p.

8. Merabishvili V.M. Cancer statistics (traditional methods, new information technologies). Guideline for physicians. Part I. 2nd edn., suppl. Saint Petersburg: Kosta, 2015. 223 p. (In Russ.).

9. Analytical information systems of the onco- logical service of Russia. Materials of the All-Russian Scientific and Practical Conference of Russian Oncologists. Eds.: V.M. Merabishvili, V.V. Starinsky, V.F. Semiglazov, Yu.A. Shcherbuk. Saint Petersburg, 2008. 176 p. (In Russ.).

10. Starinskiy V.V., Merabishvili V.M., Gretsovа V.I. et al. Organization and operation of the Population Cancer Registry. Methodical recommendations. Moscow, 2001. 14 p. (In Russ.).

11. Malignant tumors in Russia in 2003 (morbidity and morta-lity). Eds.: V.I. Chissov, V.V. Starinskiy, G.V. Petrova. Moscow: MNIOI im. P.A. Gertsena – filial FGBU “NMITS radiologii” Minzdrava Rossii, 2005. 256 p. (In Russ.).

12. Egorova A.G., Orlov A.E., Somov A.N. et al. Malignant neoplasms in the Samara region: a review of statistical information for the period 2003–2015. Part IV. Cumulative survival at 4-year intervals: 2003–2006 and 2007–2010, 2004–2007 and 2008–2011. Eds.: A.E. Orlov, S.A. Suslin, S.V. Kozlov. Saratov: Amirit, 2017. 255 p. (In Russ.).

13. Nizamova R.S., Trubin A. Yu., Gubanov E.S., Boryaev E.A. Survival in bladder cancer: monograph. Samara: IP Nikiforov M.V., 2017. 206 p. (In Russ.).

14. Petrova G.V., Gretsova O.P., Kaprin A.D., Starinskiy V.V. Characteristics and methods for calculating medical and statistical indicators used in oncology. Moscow: MNIOI im. P.A. Gertsena – filial FGBU “NMITS radiologii” Minzdrava Rossii, 2014. 40 p. (In Russ.).

15. The size and distribution of the population of the Samara region: Statistical collection. Samarastat, 2012. 113 p. (In Russ.).

16. Nizamova R.S., Pryanichnikova M.B., Gavrilova T.A. Gender differences in the incidence of bladder cancer in the Samara region. Kazanskiy meditsinskiy zhurnal = Kazan Medical Journal 2009;90(6):904–7. (In Russ.).

17. Korabelnikov A.S., Nizamova R.S. Adjusted survival of patients with bladder cancer in the Samara region in different age and gender groups. Onkologiya i radiologiya Kazahstana = Oncology and Radiology of Kazakhstan 2019;4(54):10. (In Russ.).

18. Khizha V.V., Movchan K.N., Popov S.V. et al. The statistical datа of cancer cases in SaintPetersburg within 2011–2015. Vestnik Sankt-Peterburgskogo universiteta = Bulletin of Saint Petersburg University 2017;2(1):60–82. (In Russ.). DOI: 10.21638/11701/spbu11.2017.106

19. Zalutskiy I.V., Antonenkova N.N., Prudyvus I.S. Survival of cancer patients in the Republic of Belarus in 1991–2005. Minsk: VEVER, 2008. P. 339 (In Russ.).