Efficacy and safety of adjuvant therapy with nivolumab or placebo in high-risk patients with muscle-invasive urothelial carcinoma after radical surgery: review of the first results of the randomized phase III trial CheckMate 274
https://doi.org/10.17650/1726-9776-2021-17-1-108-119
Abstract
This article analyzes first results of the randomized phase III clinical trial CheckMate 274 that has demonstrated the advantage of adjuvant immunotherapy with nivolumab, a PD-1 inhibitor, over placebo in high-risk patients with muscle-invasive urothelial carcinoma after radical surgery
About the Authors
M. I. Volkova
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Competing Interests:
Russian Federation
24 Kashirskoe Shosse, Moscow 115478.
Competing Interests:
No
A. S. Olshanskaya
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia; N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation
Competing Interests:
Russian Federation
24 Kashirskoe Shosse, Moscow 115478; 1 Ostrovityanova St., Moscow 117997.
Competing Interests:
No
S. A. Kalinin
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation
Competing Interests:
Russian Federation
1 Ostrovityanova St., Moscow 117997.
Competing Interests:
No
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Review
For citations:
Volkova M.I., Olshanskaya A.S., Kalinin S.A. Efficacy and safety of adjuvant therapy with nivolumab or placebo in high-risk patients with muscle-invasive urothelial carcinoma after radical surgery: review of the first results of the randomized phase III trial CheckMate 274. Cancer Urology. 2021;17(1):108-119. (In Russ.) https://doi.org/10.17650/1726-9776-2021-17-1-108-119
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