International experience of using olaparib for metastatic castration-resistant prostate cancer: literature review
https://doi.org/10.17650/1726-9776-2020-16-4-197-206
Abstract
The following review presents a problem of metastatic castration-resistant prostate cancer and its association with germline or somatic mutations in homologous recombination repair (HRR). In 2020, olaparib was approved in the Russian Federation as a monotherapy for metastatic castration-resistant prostate cancer with germline or somatic mutations of genes involved in DNA repair by homologous recombination, after progression on therapy with new hormonal drugs. We describe a review of the main olaparib clinical trials assessing its efficacy, safety and tolerance in metastatic castration-resistant prostate cancer patients.
About the Authors
V. B. Matveev
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Competing Interests: not
Russian Federation
24 Kashirskoe Shosse, Moscow 115478
Competing Interests: not
O. A. Khalmurzaev
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Competing Interests: not
Russian Federation
24 Kashirskoe Shosse, Moscow 115478
Competing Interests: not
O. I. Evsyukova
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Competing Interests: not
Russian Federation
24 Kashirskoe Shosse, Moscow 115478
Competing Interests: not
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Review
For citations:
Matveev V.B., Khalmurzaev O.A., Evsyukova O.I. International experience of using olaparib for metastatic castration-resistant prostate cancer: literature review. Cancer Urology. 2020;16(4):197-206. (In Russ.) https://doi.org/10.17650/1726-9776-2020-16-4-197-206
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