Bladder cancer: what’s new in 2019—2020
https://doi.org/10.17650/1726-9776-2020-16-4-147-154
Abstract
This review aims to summarize the latest data on the treatment of bladder cancer published during the specified period. Most of them are evidence-based and were obtained in randomized trials. A new classification based on molecular data was proposed at a consensus meeting of pathologists. A significant correlation has been demonstrated between life expectancy and morphological structure of the tumor. This article covers chemotherapy regimens for patient with BCG (Bacillus Calmette-Guerin) intolerance. Immunotherapeutic agents for muscle-invasive bladder cancer are being actively studied now; scientists are searching for the best treatment regimens with these drugs and their combinations with other antitumor agents. The European Association of Urology has developed a new classification of intraoperative adverse events and recommendations for pharmacotherapy and surgical treatment of patients with bladder cancer during the COVID-19 pandemic. In conclusion, the opinions of experts from the consensus meeting on the treatment of various forms of bladder cancer are given.
About the Author
O. B. KaryakinRussian Federation
4 Koroleva St., Obninsk 249031
Competing Interests: not
References
1. Kamoun A., De Reynies A., Allory Y. et al. A consensus molecular classification of muscle-invasive bladder cancer. Eur Urol 2020;77(4):420-3. DOI: 10.1016/j.eururo.2019.09.006.
2. Yanagisawa T., Miki J., Sakanaka K. et al. MP73-03 clinical significance of horizontal and vertical margin of EN-BLOC TURBT specimen. J Urol 2020;203:1121-2. DOI: 10.1097/JU.0000000000000959.03.
3. Sathianathen N., Gantz J., Alarid-Escudero F. et al. MP73-07 intravesical chemotherapy for low grade bladder cancer: a cost analysis. J Urol 2020;203:1123-4. DOI: 10.1097/JU.0000000000000959.07.
4. Adele Caruso A., Ravishankar R., VanArsdalen K. et al. MP73-08 intravesical gemcitabine and docetaxol in heavily PRE-TREATED patients with non-muscle invasive bladder cancer (NMIBC). J Urol 2020;203:1123-4. DOI: 10.1097/JU.0000000000000959.08.
5. Herr H. PD51-04 bladder - sparing surgery (BSS) for muscle invasive bladder cfncer (MIBC) after complete response to neoadjuvant chemotherapy (NAC). J Urol 2020;203:1084. DOI: 10.1097/JU.0000000000000953.04.
6. Kool R., Marcq G., Busca J. et al. PD60-01 definitive radiation-based therapy for muscle-invasive bladder cancer: the Canadian multicenter experience. J Urol 2020;203:1273. DOI: 10.1097/JU.0000000000000977.01.
7. Shou J., Cao C., Jiang W. et al. PD51-07 oncologic and functional effectiveness of neoadjuvant chemotherapy followed by surgery plus concurrent chemoradiotherapy or cystectomy for muscle-invasive bladder cancer: preliminary results of a prospective phase II stude. J Urol 2020;203:1085. DOI: 10.1097/JU.0000000000000953.07.
8. Nathan Suskovic N., Raldow A., Royce T. et al. PD55-03 cost-effectiveness of radical cystectomy vs. Trimodality therapy for muscle-invasive bladder cancer. J Urol 2020; 203:1182-3. DOI: 10.1097/JU.0000000000000965.03.
9. European Association of Urology. Guidelines 2020.
10. Elsayed A., Zhe Jing Z., Osei J. et al. PD55-10 outcomes of robot-assisted radical cystectomy in North America vs Europe: results from the international robotic cystectomy consortium. J Urol 2020;203:1186. DOI: 10.1097/JU.0000000000000965.010.
11. Vuky J., Balar A.V., Castellano D. et al. Long-term outcomes in KEYNOTE-052: phase II study investigating first-line pembrolizumab in cisplatin-ineligible patients with locally advanced or metastatic urothelial cancer. J Clin Oncol 2020;38(23):2658-66. DOI: 10.1200/JCO.19.01213.
12. Grivas P., Plimack E.R., Balar A.V. et al. Pembrolizumab as first-line therapy in cisplatin-ineligible advanced urothelial cancer (KEYNOTE-052): outcomes in older patients by age and performance status. Eur Urol Oncol 2020;3(3):351. DOI: 10.1016/j.euo.2020.02.009.
13. Necchi A., Raggi D., Bandini M. et al. PD51-01 interim results of PEANUT: an open-label, single-arm, phase 2 study evaluating pembrolizumab plus nanoparticle albumin-bound paclitaxel (nab-paclitaxel) as salvage therapy for metastatic urothelial carcinoma (UC). J Urol 2020;203:1083. DOI: 10.1097/JU.0000000000000953.01.
14. Biyani C.S., Pecanka J., Roupret M. et al. Intraoperative Adverse Incident Classification (EAUiaiC) by the European Association of Urology ad hoc Complications Guidelines Panel. Eur Urol 2020;77(5):601-10. DOI: 10.1016/j.eururo.2019.11.015.
15. Gillessen S., Powles T. Advice regarding systemic therapy in patients with urological cancers during the COVID-19 pandemic. Eur Urol 2020;77(6):667-8. DOI: 10.1016/j.eururo.2020.03.026.
16. Stensland K.D., Morgan T.M., Moinzadeh A. et al. Considerations in the triage of urologic surgeries during the COVID-19 pandemic. Eur Urol 2020;77(6):663-6. DOI: 10.1016/j.eururo.2020.03.027.
17. Witjes J.A., Babjuk M., Bellmunt J. et al. EAU-ESMO consensus statements on the management of advanced and variant bladder cancer - an international collaborative multistakeholder effort: under the auspices of the EAU-ESMO Guidelines Committees. Eur Urol 2020;77(2):223-50. DOI: 10.1016/j.eururo.2019.09.035.
Review
For citations:
Karyakin O.B. Bladder cancer: what’s new in 2019—2020. Cancer Urology. 2020;16(4):147-154. (In Russ.) https://doi.org/10.17650/1726-9776-2020-16-4-147-154