Dynamics of survival of patients with prostate cancer at the population level, taking into account the stage of the disease and place of residence

Background. Prostate cancer (PCa) is rapidly gaining a leading position in the incidence of malignant tumors among men. With a general decrease in mortality from all oncological diseases, mortality from PCa in the Russian Federation is increasing: in 2005 there were 8192 deaths, in 2015 - 11987.

Objective of the study. Calculation and assessment of survival rates for patients with PCa in the Samara region for the period from 2010 to 2016, taking into account the stage of the disease, the place of residence of patients, a comparative analysis of the observed, adjusted and relative 5-year survival for this disease in a number of regions of Russia and in the world.

Materials and methods. The object of the study was all registered patients for the period 2010-2016, with the first established PCa.

The calculation and analysis of the observed (OS), adjusted (AS) and relative (OS) survival of 7670 patients with PCa taking into account the stage of the disease and place of residence (urban residents — 6408people, rural — 1262), registered in the database of the population cancer registry of Samara Region Clinical Oncology Clinic. The start date of the study is January 1, 2010, the end date is December 31, 2019. The calculation of survival was carried out by the dynamic (actuarial) method.

Results. When assessing the survival of patients with PCa, lower rates of observed survival were observed than adjusted, which indicates the presence of intercurrent causes of death.

During the study period, an inverse dependence of survival on the prevalence of the tumor process was revealed. The level of observed survival and adjusted survival of all patients is associated in the survival range at stages II—III: 1-year-old observed survival — 89.1 % (adjusted survival — 92.3 %), 5-year-old observed survival — 62.6 % (adjusted survival — 76.6 %).

The adjusted and relative survival rate for the urban population is higher than for the rural population, which may indicate an insufficient level of access to cancer care for patients with PCa in rural areas: the indicators of 1-year adjusted survival of urban residents are higher — 3.3 % (relative survival — 2.4 %), 5-year-old adjusted survival—7.4 % (relative survival — 10.3 %) than in patients registered in rural hospitals.

Conclusion. A comparative analysis of indicators of 1- and 5-year survival of patients with PCa in the Samara region and a number of regions of the Russian Federation for 2006—2010 revealed that domestic indicators of 1-year and 5-year relative survival are slightly lower than the European average for 2000—2007. The range of indicators of the 5-year relative survivalfor 2010—2013 in the Samara region amounted to 82.2—93.1 %.

1. Merabishvili V.M. Survival of cancer patients. Saint-Petersburg, 2011. P. 32. Part 1; 332 p. (In Russ.).

2. Malignant tumors in Russia in 2015 (morbidity and mortality). Eds.: A.D. Kaprin, V.V. Starinskiy, G.V. Petrova. Moscow: MNIOI im. P.A. Gertsena - filial FGBU “NMITS radiologii” Minzdrava Rossii, 2017. Рр. 12-36. (In Russ.).

3. Bure V.M., Parilina E.M., Rubsha A.I., Svirkina L.V. Survival analysis using the medical database of prostate cancer patients. Series 10. Vestnik SPbGU = Bulletin of Saint-Petersburg State University 2014;(2):27-34. (In Russ).

4. Galimov R.D., Rakul S.A. Survival of prostate cancer patients receiving antiandrogen therapy. Meditsinskiy vestnik Bashkortostana. Ufa = Medical Bulletin of Bashkortostan. Ufa 2011;6(2):156-9. (In Russ).

5. Nizamova R.S. Survival of patients with malignant bladder tumors in Samara region. Sibirskiy onkologicheskiy zhurnal = Siberian Journal of Oncology 2009;(1):31-5. (In Russ)..

6. Nizamova R.S., Trubin A.Yu., Gubanov E.S., Boryaev E.A. Survival for bladder cancer. Moscow - Samara: IP Nikiforov M.V., 2017. 206 p. (In Russ)..

7. Nizamova R.S., Trubin A.Yu., Zimichev A.A. Dynamics of the incidence of bladder cancer in Samara region. Aspirantskiy vestnik Povolzhya = Aspirant Bulletin of the Volga Region. Samara 2016;(5-6):135-40. (In Russ)..

8. Sukonko O.G., Krasnyy S.A., Okeanov A.E. et al. Prostate cancer in Belarus: yesterday, today, and tomorrow. Zdravookhranenie. Minsk = Health Care. Minsk 2013;(11):34-42. (In Russ)..

9. Merabishvili V.M., Chepik O.F., Merabishvili E.N. Dynamics of observed and relative survival of patients with primary liver cancer on the population level according to disease stage and histological structure. Sibirskiy onkologicheskiy zhurnal = Siberian Journal of Oncology 2015;1(4):5-11. (In Russ)..

10. Choynzonov E.L., Zhuykova L.D., Ananina О.А. et al. Survival of lung cancer patients residing in Tomsk region (20042013). Sibirskiy onkologicheskiy zhurnal = Siberian Journal of Oncology 2017;16(4):5-10. (In Russ).. DOI: 10.21294/1814-4861-2017-16-4-5-10.

11. Merabishvili V.M. Adjusted and unadjusted survival of cancer patients (population study). Health Care Organization. Saint-Petersburg, 2012. Pp. 25-29. (In Russ).

12. Orlov A.E., Kozlov S.V., Egorova A.G., Vozdvizhenskiy M.O. State and outlooks of the development and improvement of cancer care in Samara region. Izvestiya Samarskogo nauchnogo tsentra Rossiyskoy akademii nauk = Journal of Samara Research Center of the Russian Academy of Sciences 2015;17(2(3)):611-7. (In Russ)..

13. Malignant tumors in Russia in 2016 (morbidity and mortality). Eds.: A.D. Kaprin, V.V. Starinskiy, G.V. Petrova. Moscow: MNIOI im. P.A. Gertsena - filial FGBU “NMITS radiologii” Minzdrava Rossii, 2018. 250 p. (In Russ.).

14. Berezkin D.P. Method for calculating unadjusted and adjusted survival rates in cancer patients. Voprosy onkologii = Problems in Oncology 2010;(11):113-7. (In Russ.).

15. Petrova G.V., Gretsova O.P., Kharchenko N.V. Methods for calculating survival rates. Malignant tumors in Russia in 2003 (incidence and mortality). Eds.: V.I. Chissov, V.V. Starinskiy, G.V. Petrova. Moscow: MNIOI im. P.A. Gertsena - filial FGBU “NMITS radiologii” Minzdrava Rossii, 2005. 256 p. (In Russ.).

16. Petrova G.V., Gretsova O.P., Starinskiy V.V. Characteristics and methods of calculating statistical parameters used in oncology. Moscow, 2005. 39 p. (In Russ.).

17. Merabishvili V.M. Cancer statistics (traditional methods and new information technologies). Guideline for doctors. Part II. Saint-Petersburg, 2015. P. 248. (In Russ.).

18. MerabbshviiiV.M. Malignant tumors in the North-West Federal District of Russia (morbidity, mortality, contingents, survival of patientd). Express-information. 4th issue. Manual for doctors. Ed. Prof. A.M. Belyaev. Saint-Petersburg, 2018. Pp. 333-414. (In Russ.).

19. Survival of Cancer Patients in Europe The EUROCARE. 5 Study: Section 1: Survival Analysis 2000-2007. Available at: https://w3.iss.it/site/EU5Results/forms/SA0007.aspx (date of the application 06.11.2019).

20. SEER cancer Statistics Review 19752016. Available at: https://seer.cancer.gov/csr/1975_2016/results_merged/sect_23_prostate.pdf (date of the application 06.01.2020).

21. Egorova A.G., Orlov A.E., Somov A.N. et al. Malignant tumors in Samara region: review of statistical information for 20032015. Part II. Dynamics of 5-year, 4-year, and 1-year survival. Eds.: DSc A.E. Orlova, DSc S.A. Suslina, DSc S... Kozlova, DSc R.S. Nizamova. Saratov: Amirit, 2017. P. 148. (In Russ.).

22. Zalutskiy I..., Antonenkova N.N., Prudyvus I.S. Survival of cancer patients in Belarus in 1991-2005. Minsk, 2008. Pp. 338, 339. (In Russ.).

23. World Health Statistics: Mortality and global health estimates. Available at: http://apps.who.int/gho/data/node.main (date of the application 08.05.2016).

24. State of oncological care in Russia in 2018. Eds.: A.D. Kaprin, Starinskiy, G... Petrova. Moscow: MNIOI im. P.A. Gertsena - filial FGBU “NMITS radiologii” Minzdrava Rossii, 2019. Pp. 25, 26. (In Russ.).