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Profuse bleedings from the rectum and bladder as complications of radiotherapy for prostate cancer

https://doi.org/10.17650/1726-9776-2006-2-2-59-61

Abstract

Among more than 300 patients with end-stage radiation-induced bladder and rectal lesions treated at different institutions of Russia, the authors observed 38 patients with severe profuse hemorrhage after megavoltage radiotherapy for localized forms of prostate cancer. The pathogenetic mechanisms of a radiation lesion and profuse bleeding from the bladder and rectum are substantiated. Effective treatments in such patients are given.

About the Authors

M. S. Bardychev
Medical Radiology Research Center, Russian Academy of Medical Sciences
Russian Federation
Obninsk


V. V. Pasov
Medical Radiology Research Center, Russian Academy of Medical Sciences
Russian Federation
Obninsk


A. K. Kurpesheva
Medical Radiology Research Center, Russian Academy of Medical Sciences
Russian Federation
Obninsk


O. V. Terekhov
Medical Radiology Research Center, Russian Academy of Medical Sciences
Russian Federation
Obninsk


Zh. M. Niyazova
Medical Radiology Research Center, Russian Academy of Medical Sciences
Russian Federation
Obninsk


D. M. Berdychev
Medical Radiology Research Center, Russian Academy of Medical Sciences
Russian Federation
Obninsk


References

1. Lebesque J., Koper P., Slot A. et al. Acute and late GI and GU toxicity after prostate irradiation to doses of 68 Gy and 78 Gy: results of a randomized trial. Int J Radiat Biol Phys 2003; 57: 152.

2. Sydes M.R., Stephens R.I., Moore A.R. et al. Implementing the UK Medical Research Council (MRC) RTOI trial: methods and practicalities of a randomized controlled trial of conformal radiotherapy in men with localized prostate cancer. Radiother Oncol 2004; 72: 199–211.

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4. Бардычев М.С., Терехов О.В. Лучевые циститы и их лечение с применением гепона – иммуномодулятора с противовоспалительной активностью. Фарматека 2004; 12: 65–8.

5. Kaneda T., Akita S., Usami Y. et al. Clinical radio-protective anti-inflammatory effects by syperoxide dismutase. J Jpn Soc Cancer Ther 1984, 19: 811–9.


Review

For citations:


Bardychev M.S., Pasov V.V., Kurpesheva A.K., Terekhov O.V., Niyazova Zh.M., Berdychev D.M. Profuse bleedings from the rectum and bladder as complications of radiotherapy for prostate cancer. Cancer Urology. 2006;2(2):59-61. (In Russ.) https://doi.org/10.17650/1726-9776-2006-2-2-59-61

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ISSN 1726-9776 (Print)
ISSN 1996-1812 (Online)
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