Cytogenetic studies of bilateral renal cell carcinoma
https://doi.org/10.17650/1726-9776-2006-2-3-14-18
Abstract
Aim. To study chromosomal abnormalities in bilateral renal cell carcinoma (RCC).
Materials and methods. Paraffin-embedded specimens from 8 patients with bilateral RCC were examined by comparative genomic hybridization.
Results. 1 to 6 chromosomal aberrations were found in each sample. The same chromosomal aberrations in both tumors in 7 (87.5%) cases chromosomal changes were different in one (12.5%) case.
Conclusion. Further genetic studies of bilateral RCC may give a better insight into the biology, diagnosis, and treatment of bilateral RCC.
About the Authors
V. B. Matveyev
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
Russian Federation
Russian Federation
T. V. Marilov
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
Russian Federation
Russian Federation
K. Junker
Jena University Urology Clinic
Germany
Germany
References
1. Базов И.В., Казубская Т.П., Ермилова В.Д. и др. Картирование аллельных делеций на коротком плече хромосомы 3 человека в опухолях почки. Мол биол 2001;35(3)404–12.
2. Bentz M., Bergerheim U.S., Li C. et al. Chromosome imbalance in papillary renal cell carcinoma and first cytogenetic data of familial cases analyzed by comparative genomic hybridization. Cytogenet Cell Genet 1996;75:17–21.
3. Cohen A.J., Li P.B., Berg S. et al. Hereditary renal cell carcinoma associated with a chromosomal translocation. N Engl J Med 1979;301:592–5.
4. Costello J.F., Plass Ch. Methylation matters. J Med Genet 2001;38:285–303.
5. Kallioniemi A., Kallioniemi O., Sudar D. et al. Comparative genomic hybridization: a powerfull new methoв for cytogenetic analysis of solid tumors. Science 1992;258:818–21.
6. Kito H., Suzuki H., Igarashi T. et al. Distinct patterns of chromosomal losses in clinically synchronous and asynchronous bilateral; rena cell carcinoma. J Urol 2002;(168):2637–40.
7. Kovacs G., Tory K., Kovacs A. Development of papillary renal cell tumours is assossiated with loss of Y-chromosome-specific DNA sequences. J Pathol 1994;173:39.
8. Miyazaki T., Yamashita Y., Yoshimatsu S. et al. Renal cell carcinomas in von Hippel-Lindau disease; tumor detection and management. Comput Med Imaging Graph 2000;24(2):105–13.
9. Speicher M.R., Schoell B., du Manoir S. et al. Specific loss of chromosomes 1,2,6,10,13,17 and 21 in chromophobe renal cell carcinoma revealed by comparative genomic hybridization. Am J Pathol 1994;145:356–64.
10. van den Berg A., Buys C.H. Involvement of multiple loci on chromosome 3 in renal cell cancer development. Genes Chromosome Cancer 1997;19(2):59–76.
11. Zambrano N.R., Lubensky I.A., Merino M.J. et al. Histopatologic and molecular genetics of renal tumors: towards unification of classification system. J Urol 1999;162:1246–58.
Review
For citations:
Matveyev V.B., Marilov T.V., Junker K. Cytogenetic studies of bilateral renal cell carcinoma. Cancer Urology. 2006;2(3):14-18. (In Russ.) https://doi.org/10.17650/1726-9776-2006-2-3-14-18
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