Clinical application of FISH method in the early diagnostics of superficial bladder cancer
https://doi.org/10.17650/1726-9776-2008-4-4-61-65
Abstract
Patients with primary diagnosis of bladder cancer (42 persons) were studied. FISH analysis performed in all patients showed the following results: 39 (93%) patients were FISH positive and 3 (7%) were FISH negative. The molecular cytogenetic criterion for determining the grade of differentiation of Ta and T1 tumors — chromosomal hyperploidy in morphologically abnormal cells, was suggested. All patients demonstrating increased amount (more than 26%) of abnormal cell with hyperploidy of chromosomes 3, 7 and 17 were found to have high grade malignancies.
About the Authors
A. V. Sevankaev
Medical Radiological Research Centre of Russian Academy of Medical Sciences
Russian Federation
Russian Federation
Department of radiotherapy and surgery of urologic disorders, clinical morphologic department, laboratory of molecular cytogenetics
E. F. Lushnikov
Medical Radiological Research Centre of Russian Academy of Medical Sciences
Russian Federation
Russian Federation
Department of radiotherapy and surgery of urologic disorders, clinical morphologic department, laboratory of molecular cytogenetics
O. B. Karyakin
Medical Radiological Research Centre of Russian Academy of Medical Sciences
Russian Federation
Russian Federation
Department of radiotherapy and surgery of urologic disorders, clinical morphologic department, laboratory of molecular cytogenetics
G. F. Mikhailova
Medical Radiological Research Centre of Russian Academy of Medical Sciences
Russian Federation
Russian Federation
Department of radiotherapy and surgery of urologic disorders, clinical morphologic department, laboratory of molecular cytogenetics
N. A. Gorban
Medical Radiological Research Centre of Russian Academy of Medical Sciences
Russian Federation
Russian Federation
Department of radiotherapy and surgery of urologic disorders, clinical morphologic department, laboratory of molecular cytogenetics
S. V. Bashkatov
Medical Radiological Research Centre of Russian Academy of Medical Sciences
Russian Federation
Russian Federation
Department of radiotherapy and surgery of urologic disorders, clinical morphologic department, laboratory of molecular cytogenetics
E. V. Goloub
Medical Radiological Research Centre of Russian Academy of Medical Sciences
Russian Federation
Russian Federation
Department of radiotherapy and surgery of urologic disorders, clinical morphologic department, laboratory of molecular cytogenetics
T. G. Shkavrova
Medical Radiological Research Centre of Russian Academy of Medical Sciences
Russian Federation
Russian Federation
Department of radiotherapy and surgery of urologic disorders, clinical morphologic department, laboratory of molecular cytogenetics
V. V. Tsepenko
Medical Radiological Research Centre of Russian Academy of Medical Sciences
Russian Federation
Russian Federation
Department of radiotherapy and surgery of urologic disorders, clinical morphologic department, laboratory of molecular cytogenetics
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Review
For citations:
Sevankaev A.V., Lushnikov E.F., Karyakin O.B., Mikhailova G.F., Gorban N.A., Bashkatov S.V., Goloub E.V., Shkavrova T.G., Tsepenko V.V. Clinical application of FISH method in the early diagnostics of superficial bladder cancer. Cancer Urology. 2008;4(4):61-65. (In Russ.) https://doi.org/10.17650/1726-9776-2008-4-4-61-65
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