The validation of threshold decision ruls and calculator for APhiG algoritm for clarification of prostate cancer staging before treatment

N. S. Sergeeva; Сергеева Н. С.; T. E. Skachkova; Скачкова Т. Е.; N. V. Marshutina; Маршутина Н. В.; K. M. Nushko; Нюшко К. М.; I. M. Shevchuk; Шевчук И. М.; M. R. Nazirov; Назиров М. Р.; B. Ya. Alekseev; Алексеев Б. Я.; S. A. Pirogov; Пирогов С. А.; E. F. Yurkov; Юрков Е. Ф.; V. G. Gitis; Гитис В. Г.; A. D. Kaprin; Каприн А. Д.

doi:10.17650/1726-9776-2020-16-1-43-53

The validation of threshold decision ruls and calculator for APhiG algoritm for clarification of prostate cancer staging before treatment

Authors: Sergeeva N.S.¹^,2, Skachkova T.E.¹, Marshutina N.V.¹, Nushko K.M.¹, Shevchuk I.M.³, Nazirov M.R.³, Alekseev B.Y.⁴, Pirogov S.A.⁵, Yurkov E.F.⁵, Gitis V.G.⁵, Kaprin A.D.⁴
Affiliations:
1. P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center, Ministry of Health of Russia
2. N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
3. N.A. Lopatkin Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiological Center, Ministry of Health of Russia
4. National Medical Research Radiological Center, Ministry of Health of Russia
5. Institute for Information Transmission Problems (Kharkevich Institute), Russian Academy of Sciences
Issue: Vol 16, No 1 (2020)
Pages: 43-53
Section: DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. PROSTATE CANCER
Published: 30.03.2020
URL: https://oncourology.abvpress.ru/oncur/article/view/997
DOI: https://doi.org/10.17650/1726-9776-2020-16-1-43-53
ID: 997

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Abstract
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Abstract

Background. We have previously described an algorithm APhiG (Age of patients, Prostate health index and Gleason score), for staging of prostate cancer before treatment. The algorithm was developed by logistic regression on a training dataset and validated on a validation dataset (VD). Objective. Validation of threshold decision rules and a program for APhiG calculation on the VD.

Materials and methods. ROC curve analysis on VD (83 cases).

Results and conclusion. It was shown that sensitivity, specificity, positive and negative predictive value, diagnostic accuracy threshold decision rules and area under the curve (AUC) for APhiG in the VD (n = 83) not significantly different from those indicators in the training dataset (n = 337), which was the basis for the algorithm APhiG development.

Keywords

prostate cancer, staging before treatment, APhiG algorithm, validation

About the authors

N. S. Sergeeva

P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center, Ministry of Health of Russia;
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Author for correspondence.
Email: prognoz.01@mail.ru
ORCID iD: 0000-0001-7406-9973

3 2nd Botkinskiy Proezd, Moscow 125284;

1 Ostrovityanovа St., Moscow 117997

Russian Federation

References

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Sergeeva N.S., Gitis V.G., Yurkov E.F. et al. A method for predicting the stage and aggressiveness of prostate cancer before surgery on laboratory and clinical parameters. Patent for invention. RU 2614501 C1. IPC G01N 33/48 of 03/28/2017. (In Russ.).
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Sergeeva N.S., Skachkova T.E., Marshutina N.V. et al. The validation results for APhiGT algorithm for clarification of prostate cancer staging before treatment (first step). Cancer Urology. 2019; 15 (2):72-82. doi: 10.17650/1726-9776-2019-15-2-42-52. (In Russ.).
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