The validation results for APhiGT algorithm for clarification of prostate cancer staging before treatment (first step)
N. S. Sergeeva,
T. E. Skachkova,
N. V. Marshutina,
K. M. Nushko,
I. M. Shevchuk,
M. R. Nazirov,
S. A. Pirogov,
E. F. Yurkov,
V. G. Gitis,
B. Ya. Alekseev,
A. D. Kaprin https://doi.org/10.17650/1726-9776-2019-15-2-42-52
Abstract
Background. We have previously described an algorithm APhiGT (Age, Prostate Health index, Gleason score, TNM stage) for staging of prostate cancer (PC) before treatment. The algorithm was developed by logistic regression on an educational selection (ES) of 337 PC cases. The algorithm includes data about the age of patients, the levels of total prostate-specific antigen (PSA), free PSA, [-2]proPSA and the ranked data of the Gleason score (by biopsy results) and T (by TNM).
Objective. Validation of APhiGT on the validation selection (VS) of 83 PC cases was carried out in this work.
Materials and methods. ROC analysis was performed in ES and VS.
Results and сonclusion. It is established that area under the curve (AUC), characterizing the ability to divide clinically significant subgroups of patients (Gleason score <7 vs. Gleason score ≥7, рТ2 vs. рТ3, localized indolent PC vs. localized aggressive PC) for APhiGT both in ES and VS was significantly higher than AUC for total PSA, %[-2]proPSA in free PSA and prostate health index. At the same time, in all clinical subgroups of patients AUC for VS was lower than AUC for ES, which may be due to a significantly smaller size of VS compared to ES.
About the Authors
N. S. Sergeeva
P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center, Ministry of Health of Russia;
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
3 2nd Botkinskiy Proezd, Moscow 125284,
1 Ostrovityanovа St., Moscow 117997
T. E. Skachkova
P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center, Ministry of Health of Russia
Russian Federation
Russian Federation
3 2nd Botkinskiy Proezd, Moscow 125284
N. V. Marshutina
P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center, Ministry of Health of Russia
Russian Federation
Russian Federation
3 2nd Botkinskiy Proezd, Moscow 125284
K. M. Nushko
P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center, Ministry of Health of Russia
Russian Federation
Russian Federation
3 2nd Botkinskiy Proezd, Moscow 125284
I. M. Shevchuk
N.A. Lopatkin Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiological Center, Ministry of Health of Russia
Russian Federation
Russian Federation
Build. 1, 51 3rd Parkovaya St., Moscow 105425
M. R. Nazirov
N.A. Lopatkin Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiological Center, Ministry of Health of Russia
Build. 1, 51 3rd Parkovaya St., Moscow 105425
S. A. Pirogov
Institute for Information Transmission Problems (Kharkevich Institute), Russian Academy of Sciences
Russian Federation
Russian Federation
Build. 1, 19 Bol’shoy Karetnyy Pereulok, Moscow 127051
E. F. Yurkov
Institute for Information Transmission Problems (Kharkevich Institute), Russian Academy of Sciences
Russian Federation
Russian Federation
Build. 1, 19 Bol’shoy Karetnyy Pereulok, Moscow 127051
V. G. Gitis
Institute for Information Transmission Problems (Kharkevich Institute), Russian Academy of Sciences
Build. 1, 19 Bol’shoy Karetnyy Pereulok, Moscow 127051
B. Ya. Alekseev
National Medical Research Radiological Center, Ministry of Health of Russia
Russian Federation
Russian Federation
4 Koroleva St., Obninsk 249031
A. D. Kaprin
National Medical Research Radiological Center, Ministry of Health of Russia
Russian Federation
Russian Federation
4 Koroleva St., Obninsk 249031
References
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Review
For citations:
Sergeeva N.S., Skachkova T.E., Marshutina N.V., Nushko K.M., Shevchuk I.M., Nazirov M.R., Pirogov S.A., Yurkov E.F., Gitis V.G., Alekseev B.Ya., Kaprin A.D. The validation results for APhiGT algorithm for clarification of prostate cancer staging before treatment (first step). Cancer Urology. 2019;15(2):42-52. (In Russ.) https://doi.org/10.17650/1726-9776-2019-15-2-42-52
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