Email this article 
DIAGNOSTIC VALUE OF TRF1 AND MMP-7 AGAINST VARIOUS PROSTATE NEOPLASMS
- Authors: Avdoshin V.P.1, Apryatin S.A.2, Pulbere S.A.1, Gordeev S.A.2, Glukhov A.I.3
-
Affiliations:
- Department of Urology and Surgical Nephrology, Russian Peoples Friendship University, Moscow
- Moscow Research Institute of Medical Ecology, Moscow Department of Healthcare
- Moscow Research Institute of Medical Ecology, Moscow Department of Healthcare Department of Biochemistry, I.M. Sechenov Moscow State Medical University
- Issue: Vol 7, No 1 (2011)
- Pages: 31-36
- Section: PROSTATE CANCER
- Published: 30.03.2011
- URL: https://oncourology.abvpress.ru/oncur/article/view/75
- DOI: https://doi.org/10.17650/1726-9776-2011-7-1-31-36
- ID: 75
Cite item
Full Text
Abstract
The authors analyzed the relative levels of telomeric repeat-binding protein factor 1 (TRF1) and matrix metalloproteinase-7 (MMR-7) mRNA expression by the cells obtained from prostate biopsy specimens of patients with benign prostate hyperplasia and cancer (PC) and healthy men without visible prostate diseases and calculated a TRF1/MMR-7 expression ratio for the above conditions. There was a statistically significant difference in the levels of TRF1 and MMP-7 expression and TRF1/MMP-7 ratio in the study groups, which may be suggestive of the high diagnostic value of these markers in determining the early-stage of PC and which enables clinicians to make a more accurate diagnosis in patients with various urologic diseases.
About the authors
V. P. Avdoshin
Department of Urology and Surgical Nephrology, Russian Peoples Friendship University, Moscow
Email: apryatin@mail.ru
Кафедра урологии и оперативной нефрологии Russian Federation
S. A. Apryatin
Moscow Research Institute of Medical Ecology, Moscow Department of Healthcare
Author for correspondence.
Email: apryatin@mail.ru
Russian Federation
S. A. Pulbere
Department of Urology and Surgical Nephrology, Russian Peoples Friendship University, Moscow
Email: apryatin@mail.ru
Russian Federation
S. A. Gordeev
Moscow Research Institute of Medical Ecology, Moscow Department of Healthcare
Email: apryatin@mail.ru
Russian Federation
A. I. Glukhov
Moscow Research Institute of Medical Ecology, Moscow Department of HealthcareDepartment of Biochemistry, I.M. Sechenov Moscow State Medical University
Email: apryatin@mail.ru
Russian Federation
References
Supplementary files
