Email this article Targeted therapy in patients with poor-prognosis renal cell carcinoma
- Authors: Alekseev B.Y.1, Kalpinskiy A.S.1, Mukhomed’yarova A.A.1, Nyushko K.M.1, Kaprin A.D.1
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Affiliations:
- P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center, Ministry of Health of Russia
- Issue: Vol 13, No 2 (2017)
- Pages: 49-55
- Section: DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. RENAL CANCER
- Published: 30.06.2017
- URL: https://oncourology.abvpress.ru/oncur/article/view/687
- DOI: https://doi.org/10.17650/1726-9776-2017-13-2-49-55
- ID: 687
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Abstract
The majority of patients with metastatic renal cell carcinoma (mRCC) are in the groups of favorable or moderate prognosis per the MSKCC (MemorialSloan-KetteringCancerCenter) criteria, but in 20–30 % of poor-prognosis patients aggressive, rapidly progressing mRCC is observed. Despite improved prognosis in mRCC patients due to targeted therapy, this patient group remains hard to treat with overall survival 6 months) was higher in the temsirolimus (32.1 %) and combination (28.1 %) groups compared to the IFN-α group (15.5 %; р<0,001).
About the authors
B. Ya. Alekseev
P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center, Ministry of Health of RussiaRussian Federation
A. S. Kalpinskiy
P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center, Ministry of Health of Russia
Author for correspondence.
Email: dr.Kalpinskiy@rambler.ru
3 2nd Botkinskiy Proezd, Moscow 125284 Russian Federation
A. A. Mukhomed’yarova
P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center, Ministry of Health of RussiaRussian Federation
K. M. Nyushko
P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center, Ministry of Health of RussiaRussian Federation
A. D. Kaprin
P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center, Ministry of Health of RussiaRussian Federation
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