PREDICTORS IN PATIENTS WITH MUSCLE-INVASIVE BLADDER CANCER AFTER RADICAL CYSTECTOMY

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Abstract

Purpose. Assessment of predictors of cancer-specific survival (CSS) in patients at high risk of progression of muscle-invasive bladder cancer (MIBC) after radical cystectomy that have been included in a prospective, randomized study to assess efficacy of shortened course of adjuvant chemotherapy.

Material and methods. A total of 92 patients were included in the study. Prognostic significance of age, gender, recurrent status of urinary diversion, pT category and pN, the number of distant lymph nodes (LN), the degree of differentiation and the presence of metaplasia, the number of metastatic lesions of the LN and LN-density lesion on CSS were evaluated with Cox proportional hazard model.

Results. Factors significantly associated with the probability of death from bladder cancer were number of metastatic lymph nodes (hazard ratio (HR) 1.128; 95 % confidence interval (CI) 1.018–1.251; p = 0.022) and the density of LN involvement (HR 1.011; 95 % CI 1.001–1.022; p = 0.039).

About the authors

A. G. Zhegalik

N.N. Aleksandrov Republican Scientific-and-Practical Center of Oncology and Medical Radiology, Minsk

Author for correspondence.
Email: alex.arz@list.ru
Belarus

S. L. Polyakov

N.N. Aleksandrov Republican Scientific-and-Practical Center of Oncology and Medical Radiology, Minsk

Email: alex.arz@list.ru
Belarus

A. I. Rolevich

N.N. Aleksandrov Republican Scientific-and-Practical Center of Oncology and Medical Radiology, Minsk

Email: alex.arz@list.ru
Belarus

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