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Investigation of correlations between different prostate-specific antigen forms and clinical and morphological characteristics of a tumor process in patients with prostate cancer
- Authors: Sergeeva N.S.1,2,3, Skachkova T.E.4,3, Alekseev B.Y.1,5, Marshutina N.B.1,5, Kaprin A.D.1,5
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Affiliations:
- P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Research Radiology Center, Ministry of Health of Russia
- 3, Second Botkinsky Pr., Moscow 125284, Russia N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
- 1, Ostrovityanov St., Moscow 117997
- N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
- 3, Second Botkinsky Pr., Moscow 125284, Russia
- Issue: Vol 11, No 2 (2015)
- Pages: 89-95
- Section: PROSTATE CANCER
- Published: 30.06.2015
- URL: https://oncourology.abvpress.ru/oncur/article/view/459
- DOI: https://doi.org/10.17650/1726-9776-2015-11-2-89-95
- ID: 459
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Abstract
Serum samples from 226 primary patients with prostate cancer (PC) and a baseline total prostate-specific antigen (t-PSA) of < 30.0 ng/ml were used to investigate f-PSA and [-2]proPSA levels and to calculate f-PSA%, [-2]proPSA%, and prostate health index (PHI). The findings were compared with cancer stage (pTNM) and Gleason grade (Gleason index) in accordance with a postoperative histological report. PHI was shown to have the best differentiating properties (pT2c/pT3a/pT3b; localized indolent PC / localized aggressive PC / locally advanced PC / PC with regional metastases; Gleason score 5-6 / Gleason score 7 (3+4) / Gleason score 7 (4+3).
About the authors
N. S. Sergeeva
P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Research Radiology Center, Ministry of Health of Russia;3, Second Botkinsky Pr., Moscow 125284, Russia
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia; 1, Ostrovityanov St., Moscow 117997
Russian Federation
T. E. Skachkova
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia; 1, Ostrovityanov St., Moscow 117997
Author for correspondence.
Email: adora.wh@gmail.com
Russian Federation
B. Ya. Alekseev
P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Research Radiology Center, Ministry of Health of Russia;3, Second Botkinsky Pr., Moscow 125284, Russia
Russian Federation
N. B. Marshutina
P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Research Radiology Center, Ministry of Health of Russia;3, Second Botkinsky Pr., Moscow 125284, Russia
Russian Federation
A. D. Kaprin
P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Research Radiology Center, Ministry of Health of Russia;3, Second Botkinsky Pr., Moscow 125284, Russia
Russian Federation
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