THE ROLE OF BONE SCINTIGRAPHY IN DETECTION OF BONE METASTASES OF PROSTATE CANCER IN PATIENTS WITH BIOCHEMICAL RECURRENCE AFTER RADICAL PROSTATECTOMY
https://doi.org/10.17650/1726-9776-2012-8-4-70-76
Abstract
Objective: to evaluate the relationship between serum PSA and other variables to eliminate bone scanning (BS) in patients with biochemical recurrence (BR) after radical prostatectomy (RP) having a low probability of bone metastasis.
Material and methods. The study included 110 patients with BR after RPE between 2008 and 2012. Bone metastasis was studied for its correlation with various clinical and pathological variables in these patients.
Results. According to multivariate regression analysis the trigger PSA level, PSA doubling time and Gleason sum were independent predictors of detecting of bone metastases using scintigraphy. The frequency of bone metastases was 0 % (95% CI 0,0−14,3) in patients with PSA 5 ng/mL, PSA doubling time 6 month and Gleason sum after RP 6.
Conclusion. For patients with trigger PSA levels of 5 ng/ml or lower, PSA doubling time 6 month or less and Gleason sum 6 or less, BS may be eliminated because of the negligible risk of bone metastases.
About the Authors
P. D. Demeshko
N.N. Alexandrov National Cancer Center of Belarus, Minsk, Republic of Belarus
Belarus
Belarus
O. G. Sukonko
N.N. Alexandrov National Cancer Center of Belarus, Minsk, Republic of Belarus
Belarus
Belarus
S. A. Krasny
N.N. Alexandrov National Cancer Center of Belarus, Minsk, Republic of Belarus
Belarus
Belarus
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Review
For citations:
Demeshko P.D., Sukonko O.G., Krasny S.A. THE ROLE OF BONE SCINTIGRAPHY IN DETECTION OF BONE METASTASES OF PROSTATE CANCER IN PATIENTS WITH BIOCHEMICAL RECURRENCE AFTER RADICAL PROSTATECTOMY. Cancer Urology. 2012;8(4):70-76. (In Russ.) https://doi.org/10.17650/1726-9776-2012-8-4-70-76
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