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Онкоурология

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ВОЗМОЖНОСТИ И МЕХАНИЗМЫ ДЕЙСТВИЯ ГОРМОНАЛЬНОЙ ТЕРАПИИ У БОЛЬНЫХ КАСТРАЦИОННО-РЕЗИСТЕНТНЫМ РАКОМ ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ

https://doi.org/10.17650/1726-9776-2013-9-1-68-73

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Аннотация

Гормональная терапия является основным методом лечения местно-распространенного и/или метастатического рака предстательной железы (РПЖ), однако с течением времени у большинства пациентов возникает резистентность к терапии первой линии. Абиратерон – высокоактивный, селективный, необратимый ингибитор CYP17, предотвращающий конверсию прегненолона в дегидроэпиандростендион и прогестерона в андростендион в яичках и надпочечниках, а также непосредственно в опухолевой ткани. Данный препарат позволяет значительно улучшить показатели опухолеспецифической и общей выживаемости у больных кастрационно-резистентным РПЖ (КРРПЖ) и одобрен Управлением по контролю за пищевыми продуктами и лекарст-венными препаратами США (FDA) для лечения данной когорты пациентов. Несмотря на эффективность абиратерона, доказанную в ходе клинических исследований, с течением времени заболевание прогрессирует. Данный обзор литературы посвящен возможным механизмам развития резистентности к абиратерону. Глубокое понимание указанных механизмов может открыть новые возможности в борьбе с резистентностью и позволит улучшить показатели выживаемости больных КРРПЖ.

Об авторах

Б. Я. Алексеев
МНИОИ им. П.А. Герцена
Россия


А. Н. Андрианов
МНИОИ им. П.А. Герцена
Россия


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Для цитирования:


Алексеев Б.Я., Андрианов А.Н. ВОЗМОЖНОСТИ И МЕХАНИЗМЫ ДЕЙСТВИЯ ГОРМОНАЛЬНОЙ ТЕРАПИИ У БОЛЬНЫХ КАСТРАЦИОННО-РЕЗИСТЕНТНЫМ РАКОМ ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ. Онкоурология. 2013;9(1):68-73. https://doi.org/10.17650/1726-9776-2013-9-1-68-73

For citation:


Alekseev B.Y., Andrianov A.N. THE POSSIBILITIES AND MECHANISMS OF ACTION OF HORMONE THERAPY FOR CASTRATION-RESISTANT PROSTATE CANCER. Cancer Urology. 2013;9(1):68-73. (In Russ.) https://doi.org/10.17650/1726-9776-2013-9-1-68-73

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ISSN 1726-9776 (Print)
ISSN 1996-1812 (Online)
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