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TREATMENT FOR STAGE I TESTICULAR SEMINOMA

https://doi.org/10.17650/1726-9776-2010-6-3-7-11

Abstract

Overall survival is about 100% in patients with stage I germinogenic testicular tumors after orchifuniculectomy, which is achieved, by applying alternative adjuvant approaches. The use of approaches, such as a follow-up, chemo- and radiotherapy, may be recommended in seminoma. The paper shows the advantages and disadvantages of these methods.

About the Authors

E. A. Burova
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Russian Federation


A. A. Bulanov
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Russian Federation


A. A. Tryakin
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Russian Federation


M. Yu. Fedyanin
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Russian Federation


S. A. Tyulyandin
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Russian Federation


V. B. Matveyev
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow


References

1. Warde P., Specht L., Horwich A. et al. Prognostic factors for relapse in stage I seminoma managed by surveillance: a pooled analysis. J Clin Oncol 2002;20:4448–52.

2. de Wit R., Fizazi K. Controversies in the management of clinical stage I testis cancer.J Clin Oncol 2006;24:5482–90.

3. Aparicio J., Germa J.R., Garcia del Muro X. et al. Risk-adapted management for patients with clinical stage I seminoma: the Second Spanish Germ Cell Cancer Cooperative Group study. J Clin Oncol 2005;23(34):8717–23.

4. Fossa S.D., Horwich A., Russel J.M. Optimal planning target volume for stage I testicular seminoma: a Medical Research Council randomized trial. J Clin Oncol 1999;17:1146–54.

5. Jones W.G., Fossa S.D., Mead G.M. et al. Randomized trial of 30 versus 20 Gy in the adjuvant treatment of stage I testicular seminoma: a report on Medical Research Council Trial TE18, European Organisation for the Research and Treatment of Cancer Trial 30942 (ISRCTN18525328). J Clin Oncol 2005;23(6):1200–8.

6. Santoni R., Barbera F., Bertoni F. Stage I seminoma of the testis: a bi-institutional retrospective analysis of patients treated with radiation therapy only. Br J Urol Int 2003;92:47–52.

7. Travis L.B., Fossa S.D., Schonfeld S.J. et al. Second cancers among 40,576 testicular cancer patients: focus on long-term survivors. J Natl Cancer Inst 2005;97:1354–65.

8. Livsey J.E., Taylor B., Mobarek N. et al. Patterns of relapse following radiotherapy for stage I seminoma of the testis: implications for follow-up. Clin Oncol (R Coll Radiol) 2001;13(4):296–300.

9. Warde P., Gospodarowicz M.K., Panzarella T. et al. Stage I testicular seminoma: results of adjuvant irradiation and surveillance. J Clin Oncol 1995;13:2255–62.

10. Oliver R.T., Mead G.M., Fogarty P.J. et al. Radiotherapy versus carboplatin for stage I seminoma: updated analysis of the MRC/EORTC randomized trial (ISRCTN27163214). J Clin Oncol 2008;26 (Suppl); abstr 1.

11. Oliver R.T., Lore S., Ong J. Alternatives to radiotherapy in the management of seminoma. Br J Urol 1990;65:61–7.

12. Oliver R.T., Edmonds P.M., Ong J.Y. et al. Pilot studies of 2 and 1 course carboplatin as adjuvant for stage I seminoma: Should it be tested in a randomized trial against radiotherapy? Int J Radiat Oncol Biol Phys 1994;29:3–8.

13. Oliver R.T., Mason M.D., Mead G.M. et al. MRC TE19 collaborators and the EORTC 30982 collaborators. Radiotherapy versus single-dose carboplatin in adjuvant treatment of stage I seminoma: a randomized trial. Lancet 2005;366(9482):293–300.

14. Fizazi K., Auperin A., Le Moulec S. et al. Stage I seminoma: Can 18Flurorodeoxyglucose positron emission tomography (FDG-PET) predict occult dissemination? A phase II study. 2008 Genitourinary Cancers Symposium; abstr 280.


Review

For citations:


Burova E.A., Bulanov A.A., Tryakin A.A., Fedyanin M.Yu., Tyulyandin S.A., Matveyev V.B. TREATMENT FOR STAGE I TESTICULAR SEMINOMA. Cancer Urology. 2010;6(3):7-11. (In Russ.) https://doi.org/10.17650/1726-9776-2010-6-3-7-11

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ISSN 1726-9776 (Print)
ISSN 1996-1812 (Online)
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