Sarcomatoid carcinoma of the bladder: clinical observation and literature review

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Abstract

Sarcomatoid carcinomas of the bladder constitute a minor part of bladder tumors and are characterized by high potential for malignancy. Very aggressive and occurring predominantly in men, these tumors have both urothelial and sarcomatoid components. Given the rarity of cases described in the literature, there are no clear guidelines on the treatment of these tumors but it seems that radical cystectomy with extended pelvic lymphadenectomy is generally preferred. The article describes a clinical case of sarcomatoid carcinoma of the bladder.

About the authors

D. V. Semyonov

Saint Petersburg State University;
City Clinical Oncological Dispensary

Author for correspondence.
Email: sema.69@mail.ru
ORCID iD: 0000-0002-4335-8446

Dmitry Vladimirovich Semyonov 

7–9 Universitetskaya Naberezhnaya, Saint Petersburg 199034; 
56 Veteranov Prospekt, Saint Petersburg 198255

Russian Federation

R. V. Orlova

Saint Petersburg State University;
City Clinical Oncological Dispensary

Email: orlova_rashida@mail.ru
ORCID iD: 0000-0002-9368-5517

7–9 Universitetskaya Naberezhnaya, Saint Petersburg 199034; 
56 Veteranov Prospekt, Saint Petersburg 198255

D. V. Drobyshevsky

City Clinical Oncological Dispensary

Email: drobdenis@icloud.com

56 Veteranov Prospekt, Saint Petersburg 198255

P. A. Karlov

City Clinical Oncological Dispensary

Email: sema.69@mail.ru

56 Veteranov Prospekt, Saint Petersburg 198255

E. E. Topuzov

City Clinical Oncological Dispensary

Email: sema.69@mail.ru

56 Veteranov Prospekt, Saint Petersburg 198255

References

  1. Lobo N., Shariat S.F., Guo C.C. et al. What is the significance of variant histology in urothelial carcinoma? Eur Urol Focus 2020;6(4):653–63. doi: 10.1016/j.euf.2019.09.003
  2. Argüelles Salido E., Travado Soria P., Pérez Espejo M.P. et al. Carcinosarcoma vesical: análisis de nuestra serie y revisión de la literature [Carcinosarcoma of the bladder: report of our cases and review of the literature (In Spanish)]. Actas Urol Esp 2004;28(4):262–8. doi: 10.1016/s0210-4806(04)73074-0
  3. Lopez-Beltran A., Pacelli A., Rothenberg H.J. et al. Carcinosarcoma and sarcomatoid carcinoma of the bladder: clinicopathological study of 41 cases. J Urol 1998;159(5):1497–503. doi: 10.1097/00005392-199805000-00023
  4. Wick M.R., Swanson P.E. Carcinosarcomas: current perspectives and an historical review of nosological concepts. Semin Diagn Pathol 1993;10(2):118–27. doi: 10.1053/j.semdp.2015.10.001
  5. World Health Organization classification of tumors. Pathology and genetics of tumors of the urinary system and male genital organs. Eds.: J.N. Eble, G. Sauter, J.I. Epstein, I.A. Sesterhenn. Lyon: IARC Press, 2004.
  6. Perret L., Chaubert P., Hessler D., Guillou L. Primary heterologous carcinosarcoma (metaplastic carcinoma) of the urinary bladder: a clinicopathologic, immunohistochemical, and ultrastructural analysis of eight cases and a review of the literature. Cancer 1998;82(8):1535–49.
  7. Baschinsky D.Y., Chen J.H., Vadmal M.S. et al. Carcinosarcoma of the urinary bladder – an aggressive tumor with diverse histogenesis. A clinicopathologic study of 4 cases and review of the literature. Arch Pathol Lab Med 2000;124(8):1172–8. doi: 10.5858/2000-124-1172-COTUBA
  8. Mallik A.U., Rahman M.Z., Sarker M.M.R. Sarcomatoid carcinoma of urinary bladder: a case report. Pulse 2011;4(1):28–9. doi: 10.3329/pulse.v4i1.6961
  9. Sanchez J.E.H., Figueira Y.R., Gonzalez R.T. et al. Sarcomatoid carcinoma of the urinary bladder: a case report and review of the literature. J Med Cases 2014;5(2):116–9. doi: 10.14740/jmc1657w
  10. Bloxham C.A., Bennett M.K., Robinson M.C. Bladder carcinosarcomas: three cases with diverse histogenesis. Histopathology 1990;16(1):63–7. doi: 10.1111/j.1365-2559.1990.tb01062.x
  11. Bansal A., Kumar N., Sharma S.C. Sarcomatoid variant of urothelial carcinoma of the urinary bladder. J Can Res Ther 2013;9(4):571–3. doi: 10.4103/0973-1482.126449
  12. Wang J., Gillaspie C., Kunadharaju R. et al. Sarcomatoid urothelial carcinoma: a single cancer center experience. World J Oncol 2011;2(4):175–80. doi: 10.4021/wjon370w
  13. Peyromaure M., Beuzeboc P., Chekulaev D. et al. Carcinome sarcomatoìde de vessie à différenciation ostéosarcomateuse [Sarcomatoid carcinoma with heterologous osteoid differentiation (In French)]. Prog Urol 2006;16(3):378–80.
  14. Malla M., Wang J.F., Trepeta R. et al. Sarcomatoid carcinoma of the urinary bladder. Clin Genitourin Cancer 2016;14(5):366–72. doi: 10.1016/j.clgc.2016.03.004
  15. Spiess P.E., Tuziak T., Tibbs R.F. et al. Pseudosarcomatous and sarcomatous proliferations of the bladder. Hum Pathol 2007;38(5):753–61. doi: 10.1016/j.humpath.2006.11.014
  16. Robinson S.P., Farooq A., Laniado M., Motiwala H. The demographic features, clinical outcomes, prognosis and treatment options for patients with sarcomatoid carcinoma of the urinary bladder: a single centre experience. Int Braz J Urol 2018;44(1):45–52. doi: 10.1590/S1677-5538.IBJU.2016.0347
  17. Wallach J.B., Wang B., Sanfilippo N. High-grade hyperinvasive sarcomatoid urothelial bladder carcinoma demonstrating complete response to bladder-preserving chemoradiation. Curr Oncol 2009;16(3):55–7. doi: 10.3747/co.v16i3.396
  18. Hoshi S., Sasaki M., Muto A. et al. Case of carcinosarcoma of urinary bladder obtained a pathologically complete response by neoadjuvant chemoradiotherapy. Int J Urol 2007;14(1):79–81. doi: 10.1111/j.1442-2042.2006.01600.x
  19. Joseph R.W., Millis S.Z., Carballido E.M. et al. PD-1 and PD-L1 expression in renal cell carcinoma with sarcomatoid differentiation. Cancer Immunol Res 2015;3(12):1303–7. doi: 10.1158/2326-6066.cir-15-0150

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