Epidemiology and natural history of non-metastatic castration-resistant prostate cancer in Russia

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Abstract

Aim. To study the clinical and demographic profile of patients with non-metatstatic castration-resistant prostate cancer (nmCRPC) and clinical approaches to the treatment of nmCRPC in the context of daily medical practice before and after progression M1 stage.

Materials and methods. The multicenter non-interventional epidemiological study were included 200 patients with a documented diagnosis of nmCRPC from 2019 to 2020. Each patient visited twice: start and after 6 months. Of the 200 patients included, 9 were excluded from the analysis presented in this article: 1 patient had no information on inclusi- on criteria, 1 patient did not meet the inclusion criteria, 7 patients did not attend visit 2. Thus, data are presented for 191 patients.

Results and conclusion. The median age was 74.3 years (range 55 to 91). 72 % (137/191) had a disability group. The most common comorbidities were hypertension (n = 115) and hypercholesterolemia (n = 56). The median time from the diagnosis of prostate cancer to the development of castration resistance (diagnosis of nmCRPC) was 75 months. Prostate specific antigen (PSA) nadir (0.37 ng/ml on average) was achieved after 15 months of prostate cancer therapy (median time to reach PSA nadir). At the same time, PSA doubling time in most cases (47.6 %; 91/191) was less than 6 months, 18.8 % of persons (36/191) had PSA doubling time for more than 10 months.

About the authors

B. Ya. Alekseev

National Medical Research Radiological Center, Ministry of Health of Russia; Medical Institute of Continuing Education, Moscow State University of Food Production

Author for correspondence.
Email: byalekseev@mail.ru
ORCID iD: 0000-0002-3398-4128

3 2nd Botkinskiy Proezd, Moscow 125284; 11 Volokolamskoe Shosse, Moscow 125080

Russian Federation

K. M. Nyushko

National Medical Research Radiological Center, Ministry of Health of Russia; Medical Institute of Continuing Education, Moscow State University of Food Production

ORCID iD: 0000-0002-4171-6211

3 2nd Botkinskiy Proezd, Moscow 125284; 11 Volokolamskoe Shosse, Moscow 125080

Russian Federation

R. A. Gafanov

Russian Scientific Center of Roentgen Radiology, Ministry of Health of Russia

ORCID iD: 0000-0002-7592-0392

86 Profsoyuznaya St., Moscow 117997

Russian Federation

A. A. Kirichek

Moscow City Oncological Hospital No. 62, Moscow Healthcare Department

ORCID iD: 0000-0002-3672-2369

27 Istra, Moscow region 143423

Russian Federation

Yu. V. Anzhiganova

A.I. Kryzhanovsky Krasnoyarsk Regional Clinical Oncology Dispensary

ORCID iD: 0000-0002-8388-466X

16 1st Smolenskaya St., Krasnoyarsk 660133

Russian Federation

E. I. Kopyltsov

Omsk Clinical Oncology Dispensary

ORCID iD: 0000-0003-3165-9118

Build. 1, 9 Zavertyaeva St., Omsk 644013

Russian Federation

Yu. Yu. Sundui

City Clinical Cancer Hospital No. 1, Moscow Healthcare Department

ORCID iD: 0000-0003-1217-1491

17/1 Baumanskaya St., Moscow 105005

Russian Federation

Е. D. Pashanov

Johnson & Johnson, pharmaceutical companies

ORCID iD: 0000-0003-0080-3367

Medical Department, Janssen, pharmaceutical companies of Johnson & Johnson

Build. 2, 17 Krylatskaya St., Moscow 121614

Russian Federation

A. N. Petyushin

Johnson & Johnson, pharmaceutical companies

ORCID iD: 0000-0002-0648-2368

Medical Department, Janssen, pharmaceutical companies of Johnson & Johnson

Build. 2, 17 Krylatskaya St., Moscow 121614

Russian Federation

V. B. Matveev

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0001-7748-9527

24 Kashirskoe Shosse, Moscow 115478

Russian Federation

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