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GENETIC RISK MARKERS FOR SUPERFICIAL AND INVASIVE BLADDER CANCER
- Authors: Pavlov V.N.1, Izmailov A.A.1, Viktorova T.V.2, Izmailova S.M.1, Akhmadishina L.Z.3, Galimzyanov V.V.1, Zagidullin A.A.1
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Affiliations:
- Bashkir State Medical University, Ministry of Health and Social Development of Russia, Ufa
- Bashkir State Medical University, Ministry of Health and Social Development of Russia, Ufa Ufa Research Center, Russian Academy of Sciences
- Ufa Research Center, Russian Academy of Sciences
- Issue: Vol 7, No 2 (2011)
- Pages: 23-28
- Section: DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. URINARY BLADDER CANCER
- Published: 30.06.2011
- URL: https://oncourology.abvpress.ru/oncur/article/view/134
- DOI: https://doi.org/10.17650/1726-9776-2011-7-2-23-28
- ID: 134
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Abstract
To reveal possible associations of the polymorphic variants of the cytochrome P450 and enzymes glutathione-S-transferase genes with the risk for bladder cancer (BC), the authors analyzed the frequency of genotypes and alleles at the polymorphic loci of the CYP1A1 (A2454G), GSTM1 (del), and GSTP1 (A313G) genes in 208 patients diagnosed as having BC (104 patients with invasive BC and 104 with superficial BC) and in 367 patients without identified oncopathology. The *1A*2C (OR = 3.42) and *2C*2С (OR = 6.98) genotypes, *2C (OR = 3.73) allele of the CYP1A1 gene and the GG (OR = 2.53) genotype of the GSTP1 gene were ascertained to be genetic markers for a risk for BC. The presence of the *2C (OR = 1.69) allele of the CYP1A1 gene, the G (OR = 2.40) allele and the AG genotype (OR = 2.40) of the GSTP1 gene was associated with the invasive forms of BC. There were no substantial differences in the distribution of the frequency of genotypes of the GSTM1 gene between the samples of patients and healthy individuals.
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About the authors
V. N. Pavlov
Bashkir State Medical University, Ministry of Health and Social Development of Russia, Ufa
Email: izmailov75@mail.ru
Russian Federation
A. A. Izmailov
Bashkir State Medical University, Ministry of Health and Social Development of Russia, Ufa
Author for correspondence.
Email: izmailov75@mail.ru
Russian Federation
T. V. Viktorova
Bashkir State Medical University, Ministry of Health and Social Development of Russia, UfaUfa Research Center, Russian Academy of Sciences
Email: izmailov75@mail.ru
Russian Federation
S. M. Izmailova
Bashkir State Medical University, Ministry of Health and Social Development of Russia, Ufa
Email: izmailov75@mail.ru
Russian Federation
L. Z. Akhmadishina
Ufa Research Center, Russian Academy of Sciences
Email: izmailov75@mail.ru
Russian Federation
V. V.Z. Galimzyanov
Bashkir State Medical University, Ministry of Health and Social Development of Russia, Ufa
Email: izmailov75@mail.ru
Russian Federation
A. A. Zagidullin
Bashkir State Medical University, Ministry of Health and Social Development of Russia, Ufa
Email: izmailov75@mail.ru
Russian Federation
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